Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2022; 14(4): 897-919
Published online Apr 15, 2022. doi: 10.4251/wjgo.v14.i4.897
Published online Apr 15, 2022. doi: 10.4251/wjgo.v14.i4.897
Prognostic significance of serum inflammation indices for different tumor infiltrative pattern types of gastric cancer
Yu-Fei Wang, Xin Yin, Tian-Yi Fang, Yi-Min Wang, Dao-Xu Zhang, Yao Zhang, Xi-Bo Wang, Hao Wang, Ying-Wei Xue, Department of Gastroenterological Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang Province, China
Lei Zhang, Xing-Hai Zhang, Department of Pathology, Harbin Medical University Cancer Hospital, Harbin 150081, Heilongjiang Province, China
Author contributions: Wang YF and Yin X designed and conceived this project, and they contributed equally to this work; Wang YF, Yin X, Fang TY and Wang YM, Zhang L, Zhang XH interpreted and analyzed the data; Xue YW revised the manuscript for important intellectual content; Wang YF, Yin X, Fang TY, Wang YM, Zhang L, Zhang XH, Zhang DX, Zhang Y, Wang XB, Wang H participated in the patient information collection; all authors read and approved the final manuscript.
Supported by the Harbin Science and Technology Bureau Research and Development Project of Applied Technology , No. 2017RAXXJ054 ; and Nn 10 Program of Harbin Medical University Cancer Hospital , No. Nn 10 PY 2017-03 .
Institutional review board statement: The study was approved by the Ethics Committee of the Affiliated Tumor Hospital of Harbin Medical University.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Data sharing statement: Patients’ data were saved in the Gastric Cancer Information Management System v1.2 of Harbin Medical University Cancer Hospital (Copyright No. 2013SR087424, http://www.sgihmu.com).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Wei Xue, PhD, Chief Doctor, Professor, Department of Gastroenterological Surgery, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin 150081, Heilongjiang Province, China. xueyingwei@hrbmu.edu.cn
Received: August 7, 2021
Peer-review started: August 7, 2021
First decision: October 3, 2021
Revised: October 8, 2021
Accepted: February 22, 2022
Article in press: February 22, 2022
Published online: April 15, 2022
Peer-review started: August 7, 2021
First decision: October 3, 2021
Revised: October 8, 2021
Accepted: February 22, 2022
Article in press: February 22, 2022
Published online: April 15, 2022
Core Tip
Core Tip: This is a retrospective study to analyze the relationship between peripheral circulating immune cells, inflammatory indices and the tumor infiltrative pattern (INF) types and to verify their ability to evaluate the outcome of gastric cancer (GC) patients. Our results showed that the systemic immune-inflammation index and platelet–lymphocyte ratio were independent prognostic factors for the expansive growth type, the intermediate type, and the infiltrative growth type groups. Based on different inflammatory indicators and clinicopathologic features, the nomogram models can predict the prognosis of different INF types GC patients, which deserve further testing and extension in clinical practice.