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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2022; 14(4): 842-857
Published online Apr 15, 2022. doi: 10.4251/wjgo.v14.i4.842
Published online Apr 15, 2022. doi: 10.4251/wjgo.v14.i4.842
Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α
Ling-Li Li, Ze Peng, Li-Jun Xu, Xin Zou, Dong-Mei Huang, Ping Yi, Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430045, Hubei Province, China
Qian Hu, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Yi P designed the research; Li LL, Peng Z, Xu LJ and Zou X performed the research; Xu LJ, and Zou X contributed analytic tools; Li LL and Peng Z analyzed the data; Li LL wrote the manuscript; Yi P, Hu Q and Huang DM revised the manuscript.
Supported by the National Natural Science Foundation of China , No. 81673757 and No. 81573787 .
Institutional review board statement: The study was reviewed and approved by the Huazhong University of Science and Technology Institutional Animal Care and Use Committee.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding the publication of this paper.
Data sharing statement: the data is available from the corresponding author at pyi219@163.com .
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ping Yi, PhD, MD, Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430045, Hubei Province, China. pyi219@163.com
Received: March 1, 2021
Peer-review started: March 2, 2021
First decision: October 3, 2021
Revised: October 15, 2021
Accepted: February 23, 2022
Article in press: February 23, 2022
Published online: April 15, 2022
Peer-review started: March 2, 2021
First decision: October 3, 2021
Revised: October 15, 2021
Accepted: February 23, 2022
Article in press: February 23, 2022
Published online: April 15, 2022
Core Tip
Core Tip: Hepatocyte nuclear factor 4α (HNF4α) is a member of the nuclear receptor transcription factor family, which is at the center of a complex transcriptional regulatory network and regulates the biological effects of different pathways via transcriptional regulation of differential target genes. The role of HNF4α in gastric cancer is poorly understood, so the study of the berberine targeting HNF4α in gastric cancer cell xenograft models is of great significance. In this study, we showed that the inhibition of HNF4α genes/proteins by berberine was correlated with the tumor inhibition in gastric cancer xenografts. Further experiments also indicated that berberine downregulated HNF4a to exert its antineoplastic activity in vivo.