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World J Gastrointest Oncol. Apr 15, 2022; 14(4): 820-832
Published online Apr 15, 2022. doi: 10.4251/wjgo.v14.i4.820
Management of single pulmonary metastases from colorectal cancer: State of the art
Marco Chiappetta, Lisa Salvatore, Maria Teresa Congedo, Maria Bensi, Viola De Luca, Leonardo Petracca Ciavarella, Floriana Camarda, Jessica Evangelista, Vincenzo Valentini, Giampaolo Tortora, Stefano Margaritora, Filippo Lococo
Marco Chiappetta, Maria Teresa Congedo, Leonardo Petracca Ciavarella, Jessica Evangelista, Stefano Margaritora, Filippo Lococo, Department of Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome 00168, Italy
Lisa Salvatore, Maria Bensi, Floriana Camarda, Giampaolo Tortora, Oncologia Medica Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome 00168, Italy
Viola De Luca, Vincenzo Valentini, Department of Radiation Therapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome 00168, Italy
Author contributions: Chiappetta M wrote the paper; Congedo MT, Petracca Ciavarella L, Bensi M, De Luca V and Camarda F collected the bibliography and supported manuscript drafting; Evangelista J supported manuscript drafting; Salvatore L and Lococo F revised and edited the manuscript; Margaritora S, Tortorta G and Valentini V supervised the manuscript.
Conflict-of-interest statement: No conflict-of-interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Filippo Lococo, MD, Assistant Professor, Department of Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, Rome 00168, Italy. filippo.lococo@policlinicogemelli.it
Received: March 26, 2021
Peer-review started: March 26, 2021
First decision: May 3, 2021
Revised: May 26, 2021
Accepted: March 4, 2022
Article in press: March 4, 2022
Published online: April 15, 2022
Processing time: 385 Days and 8 Hours
Core Tip

Core Tip: Single pulmonary metastasis from colorectal cancer is an uncommon scenario in which diagnostic pitfalls should be considered. Locoregional approaches (surgery more than radiotherapy or ablative procedures) might have a potential curative role with rewarding long-term results. However, since recurrences are common, the best long-term results might be expected by integrating loco-regional with systemic treatment. Moreover, despite limited evidence, different factors seem to influence prognosis in this subset of patients and should be considered when planning a tailored care strategy.