Basic Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2022; 14(11): 2122-2137
Published online Nov 15, 2022. doi: 10.4251/wjgo.v14.i11.2122
Synaptophysin-like 2 expression correlates with lymph node metastasis and poor prognosis in colorectal cancer patients
Zong-Xian Zhao, Qin-Lingfei Liu, Yao Yuan, Fu-Sheng Wang
Zong-Xian Zhao, Yao Yuan, Fu-Sheng Wang, Department of Anorectal Surgery, Fuyang People’s Hospital, Fuyang 236000, Anhui Province, China
Qin-Lingfei Liu, Department of Digestive Internal Medicine, Tianjin Medical University General Hospital, Tianjin 300070, China
Author contributions: Zhao ZX and Liu QL collected data and completed the manuscript; Yuan Y collected relevant reference and completed a part of experiment; Wang FS designed the study and assisted in writing the manuscript; and all authors read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved for publication by our Institutional Reviewer.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at 461901580@qq.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zong-Xian Zhao, MD, Researcher, Surgeon, Department of Anorectal Surgery, Fuyang People’s Hospital, No. 501 Sanqing Road, Yingzhou District, Fuyang 236000, Anhui Province, China. 461901590@qq.com
Received: July 4, 2022
Peer-review started: July 4, 2022
First decision: August 13, 2022
Revised: August 24, 2022
Accepted: October 11, 2022
Article in press: October 11, 2022
Published online: November 15, 2022
Processing time: 133 Days and 20.7 Hours
Core Tip

Core Tip: In this research, we reported the expression and biofunctions of synaptophysin-like 2 (SYPL2) in colorectal cancer (CRC) for the first time. SYPL2 correlated with lymph node metastasis and a poor prognosis (both overall and disease-free survival) in CRC. SYPL2 mainly influence CD8 T-cell and M0 macrophage enrichment in the tumor microenvironment. Gene set enrichment analysis indicated that SYPL2 might also influence the tumor vasculature development. In addition, we found that SYPL2 was correlated with the effect of bevacizumab therapy.