Systematic Reviews
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 334-347
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.334
Exosomes as potential diagnosis and treatment for liver cancer
Xiao-Cui Wei, Li-Juan Liu, Fan Zhu
Xiao-Cui Wei, Li-Juan Liu, Fan Zhu, State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy and Immunology, Department of Pathogenic Biology, School of Medicine, Wuhan University, Wuhan 430071, Hubei Province, China
Author contributions: Wei XC and Liu LJ equally contributed to this manuscript; Wei XC designed the research, drafted and revised the paper; Liu LJ analyzed the data, drafted and revised the paper; Zhu F was responsible for the design, edit, and revision of the article and supervised the manuscript; all authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81971943 and No. 81772196; and the Medical Science Advancement Program (Clinical Medicine) of Wuhan University, No. TFLC 2018003.
Conflict-of-interest statement: All authors do not have any conflicts of interest relevant to this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fan Zhu, PhD, Professor, State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy and Immunology, Department of Pathogenic Biology, School of Medicine, Wuhan University, No. 185 Donghu Road, Wuhan 430071, Hubei Province, China. fanzhu@whu.edu.cn
Received: March 22, 2021
Peer-review started: March 22, 2021
First decision: June 14, 2021
Revised: July 3, 2021
Accepted: September 8, 2021
Article in press: September 8, 2021
Published online: January 15, 2022
Processing time: 294 Days and 9.9 Hours
Core Tip

Core tip: We used a literature search to identify potential exosome diagnostic markers and novel therapeutic strategies for liver cancer. The latest literature was published in June 2021. Results were presented in tabular form, including 40 potential liver cancer biomarkers, 13 potential biotherapeutics, and 10 potential therapeutic targets for hepatocellular carcinoma. In addition, we also listed papers about exosomes as drug carriers and therapeutic factors.