Wei XC, Liu LJ, Zhu F. Exosomes as potential diagnosis and treatment for liver cancer. World J Gastrointest Oncol 2022; 14(1): 334-347 [PMID: 35116120 DOI: 10.4251/wjgo.v14.i1.334]
Corresponding Author of This Article
Fan Zhu, PhD, Professor, State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy and Immunology, Department of Pathogenic Biology, School of Medicine, Wuhan University, No. 185 Donghu Road, Wuhan 430071, Hubei Province, China. fanzhu@whu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 334-347 Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.334
Exosomes as potential diagnosis and treatment for liver cancer
Xiao-Cui Wei, Li-Juan Liu, Fan Zhu
Xiao-Cui Wei, Li-Juan Liu, Fan Zhu, State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy and Immunology, Department of Pathogenic Biology, School of Medicine, Wuhan University, Wuhan 430071, Hubei Province, China
Author contributions: Wei XC and Liu LJ equally contributed to this manuscript; Wei XC designed the research, drafted and revised the paper; Liu LJ analyzed the data, drafted and revised the paper; Zhu F was responsible for the design, edit, and revision of the article and supervised the manuscript; all authors read and approved the final manuscript.
Supported byNational Natural Science Foundation of China, No. 81971943 and No. 81772196; and the Medical Science Advancement Program (Clinical Medicine) of Wuhan University, No. TFLC 2018003.
Conflict-of-interest statement: All authors do not have any conflicts of interest relevant to this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fan Zhu, PhD, Professor, State Key Laboratory of Virology, Hubei Province Key Laboratory of Allergy and Immunology, Department of Pathogenic Biology, School of Medicine, Wuhan University, No. 185 Donghu Road, Wuhan 430071, Hubei Province, China. fanzhu@whu.edu.cn
Received: March 22, 2021 Peer-review started: March 22, 2021 First decision: June 14, 2021 Revised: July 3, 2021 Accepted: September 8, 2021 Article in press: September 8, 2021 Published online: January 15, 2022 Processing time: 294 Days and 9.9 Hours
ARTICLE HIGHLIGHTS
Research background
Liver cancer is one of the most common malignant tumors with high morbidity and mortality because of lacking early diagnosis and treatment. Exosomes have been a newly discovered cellular communication tool with high biocompatibility, low immunogenicity, and high transport efficiency. They show great potential for cancer diagnosis and therapy.
Research motivation
This review aimed to consolidate the evidence on exosomes as biomarkers for the diagnosis and therapeutics for liver cancer in a systematic fashion.
Research objectives
The main result that the authors are concerned about is discovering the great potential of exosomes in the diagnosis and treatment of liver cancer.
Table 5 Exosomes from dendritic cells as potential therapeutic factors.
Cargos
Source of exosomes
Animal model (Yes/No)
Clinical sample (Yes/No)
Functions
Ref.
Exosomes plus microwave ablation
DCs-exosomes
Y
N
Inhibit tumor growth and improve the immune microenvironment
A systematic literature search was performed using PubMed and Web of Science. The latest literature was published in June 2021.
Research results
Fifty-eight studies were included in this systematic review. Blood-derived exosomes could be biomarkers or biotherapeutics. Cell-derived exosomes, which were used to explore underlying mechanisms of differentially expressed exosome contents in clinical tissue samples, might serve as potential therapeutic targets for liver cancer. Exosomes might also serve as drug carriers or therapeutic factors.
Research conclusions
Existing studies show that exosomes have great potential for clinical application as potential novel diagnostic and therapeutic markers of liver cancer.
Research perspectives
This present review might be helpful as a reference for clinical research on exosomes in liver cancer.
