Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2021; 13(7): 716-731
Published online Jul 15, 2021. doi: 10.4251/wjgo.v13.i7.716
High expression of protein phosphatase 2 regulatory subunit B'' alpha predicts poor outcome in hepatocellular carcinoma patients after liver transplantation
Jia-Jia He, Lei Shang, Qun-Wei Yu, Ning Jiao, Shuang Qiu, Wei-Xiong Zhu, Dong-Feng Wu, Yun-Er Tian, Qing Zhang
Jia-Jia He, Qing Zhang, Clinical College of General Hospital of Chinese People's Armed Police Force, Anhui Medical University, Hefei 230032, Anhui, China
Jia-Jia He, Ning Jiao, Shuang Qiu, Wei-Xiong Zhu, Dong-Feng Wu, Yun-Er Tian, Qing Zhang, Department of Organ Transplantation, The Third Medical Center of Chinese PLA General Hospital, Beijing 100039, China
Lei Shang, Department of Health Statistics, Fourth Military Medical University, Xi'an 710032, Shanxi Province, China
Qun-Wei Yu, Department of Ophthalmology, The Third Medical Center of Chinese PLA General Hospital, Beijing 100039, China
Author contributions: He JJ, Shang L and Yu WQ contributed equally to this study; He JJ contributed to the design of the research plan, the implementation of the experiment, and the writing of the manuscript; Shang L performed the data analyses; Yu WQ performed the data collection; Jiao N and Qiu S performed the data collection and sorting; Zhu XW, Wu FD, and Tian EY reviewed the intellectual content of the article; and Zhang Q proposed research ideas and revised the final version.
Supported by National Natural Science Foundation of China, No. 81372595.
Institutional review board statement: This study was performed in compliance with the principles of the Declaration of Helsinki. The protocol was approved by the Ethics Committee of the Third Medical Center of Chinese PLA General Hospital.
Conflict-of-interest statement: The authors have no any conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Qing Zhang, PhD, Department of Organ Transplantation, Third Medical Center of Chinese PLA General Hospital, Anhui Medical University, No. 69 Yongding Road, Haidian District, Beijing 100039, China.
Received: March 21, 2021
Peer-review started: March 21, 2021
First decision: April 30, 2021
Revised: June 6, 2021
Accepted: June 23, 2021
Article in press: June 23, 2021
Published online: July 15, 2021
Core Tip

Core Tip: Protein phosphatase 2 regulatory subunit B''α (PPP2R3A) is an independent risk factor impacting the prognosis of liver transplantation (LT) in patients with hepatocellular carcinoma, with PPP2R3A being related to serum alpha-fetoprotein. PPP2R3A combined with alpha-fetoprotein can predict the prognosis of LT more accurately, supplementing the Hangzhou criteria, to a certain extent.