Systematic Reviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2021; 13(6): 625-637
Published online Jun 15, 2021. doi: 10.4251/wjgo.v13.i6.625
Current role of hepatopancreatoduodenectomy for the management of gallbladder cancer and extrahepatic cholangiocarcinoma: A systematic review
Alessandro Fancellu, Valeria Sanna, Giulia Deiana, Chiara Ninniri, Davide Turilli, Teresa Perra, Alberto Porcu
Alessandro Fancellu, Giulia Deiana, Chiara Ninniri, Teresa Perra, Alberto Porcu, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari 07100, Italy
Valeria Sanna, Unit of Oncology, AOU Sassari, Sassari 07100, Italy
Davide Turilli, Unit of Radiology, AOU Sassari, Sassari 07100, Italy
Author contributions: Fancellu A, and Porcu A contributed to this paper with conception and study design, manuscript writing and critical revision; Sanna V contributed with manuscript drafting and critical revision of oncologic outcomes; Deiana G, Ninniri C, and Perra T contributed with literature review and analysis, drafting and critical revision/editing; Turilli D contributed to tables and figures drafting; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors do not have any conflicts of interest relevant to this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist statement, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Alessandro Fancellu, FACS, MD, PhD, Associate Professor, Department of Medical, Surgical and Experimental Sciences, University of Sassari, V.le San Pietro 43, Sassari 07100, Italy.
Received: March 5, 2021
Peer-review started: March 5, 2021
First decision: March 29, 2021
Revised: April 3, 2021
Accepted: May 25, 2021
Article in press: May 25, 2021
Published online: June 15, 2021
Core Tip

Core Tip: Hepatopancreatoduodenectomy (HPD) is a complex operation that may achieve curative treatment for selected patients with locally advanced gallbladder cancer and extrahepatic cholangiocarcinoma. However, it represents a surgical procedure with high morbidity and mortality rates, that should be performed in centers with high experience in hepatobiliary-pancreatic surgery. Internationally-accepted protocols on selection criteria, preoperative assessment, operative technique, and perioperative care, are needed in order to better define which patients would benefit from HPD.