Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2021; 13(6): 472-494
Published online Jun 15, 2021. doi: 10.4251/wjgo.v13.i6.472
Current controversies and advances in the management of pancreatic adenocarcinoma
Muhammad Shehroz Zeeshan, Zeeshan Ramzan
Muhammad Shehroz Zeeshan, Zeeshan Ramzan, Gastrointestinal Section, Department of Medicine, Texas Health Harris Methodist Hospital, Fort Worth, TX 76104, United States
Author contributions: Zeeshan MS was responsible for collecting reference articles, manuscript writing and figure/table generation; Ramzan Z provided expertise in the field of gastrointestinal endoscopy, manuscript writing and editing, and designing the aims of the manuscript.
Conflict-of-interest statement: Authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zeeshan Ramzan, AGAF, FACG, Associate Professor, Gastrointestinal Section, Department of Medicine, Texas Health Harris Methodist Hospital, 1301 Pennsylvania Ave, Fort Worth, TX 76104, United States. zeeshanramzan@hotmail.com
Received: January 8, 2021
Peer-review started: January 8, 2021
First decision: February 24, 2021
Revised: March 22, 2021
Accepted: May 25, 2021
Article in press: May 25, 2021
Published online: June 15, 2021
Core Tip

Core Tip: Early diagnosis and treatment of pancreatic adenocarcinoma has remained a challenge over the last several decades. Despite best efforts, the long-term survival rate has not significantly improved. The following manuscript highlights the current advances and controversies in the management of pancreatic cancer. The standard systemic therapies have been presented in a format that is easy to read and follow. Novel approaches in diagnosis and management have been discussed in light of evidence-based medicine.