Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2021; 13(12): 2180-2189
Published online Dec 15, 2021. doi: 10.4251/wjgo.v13.i12.2180
Clinical features of intracerebral hemorrhage in patients with colorectal cancer and its underlying pathogenesis
Xu-Hui Deng, Jing Li, Shi-Jian Chen, Yi-Ju Xie, Jian Zhang, Geng-Yu Cen, Yi-Ting Song, Zhi-Jian Liang
Xu-Hui Deng, Shi-Jian Chen, Yi-Ju Xie, Jian Zhang, Geng-Yu Cen, Yi-Ting Song, Zhi-Jian Liang, Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Xu-Hui Deng, Department of Neurology, The Affiliated Yuebei People’s Hospital of Shantou University Medical College, Shaoguan 512025, Guangdong Province, China
Jing Li, Department of General Medicine, The Affiliated Cancer Center of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Deng XH and Liang ZJ conceived and designed the study; Deng XH collected the data and drafted the manuscript; Li J, Chen SJ, Xie YJ, Zhang J, Cen GY and Song YT helped to collect the data; Li J and Chen SJ analyzed the results; Liang ZJ critically revised the manuscript and provided financial support for this work; all the authors have read the manuscript and approved the final version.
Supported by The Foundation of Prevention and Control of Chronic Diseases in Central-South China (Guangxi), No. 2018YFC1311305; and the Foundation of Science and Technology Plan Projects of Qingxiu District of Nanning, No. 2020043.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Guangxi Medical University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent. For full disclosure, the details of the study are published on the home page of the First Affiliated Hospital of Guangxi Medical University.
Conflict-of-interest statement: All authors have no conflict of interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Jian Liang, MD, PhD, Professor, Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, No. 22 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. lzj200415@126.com
Received: July 5, 2021
Peer-review started: July 5, 2021
First decision: July 29, 2021
Revised: August 10, 2021
Accepted: September 15, 2021
Article in press: September 15, 2021
Published online: December 15, 2021
Processing time: 162 Days and 14.6 Hours
Core Tip

Core Tip: The association between cancer and intracerebral hemorrhage (ICH) has long been studied, however little attention has been paid to the hemorrhagic cerebrovascular events in patients with colorectal cancer (CRC). CRC has been reported to increase the risk of ICH. The present study retrospectively analyzed the clinical data of patients with CRC and ICH, and indicated that intratumoral hemorrhage and coagulopathy were the main causes of ICH in CRC patients.