Published online Dec 15, 2021. doi: 10.4251/wjgo.v13.i12.2180
Peer-review started: July 5, 2021
First decision: July 29, 2021
Revised: August 10, 2021
Accepted: September 15, 2021
Article in press: September 15, 2021
Published online: December 15, 2021
The diagnosis of both cancer and intracerebral hemorrhage (ICH) in the same patient is not uncommon, but the clinical features and pathogenesis of patients with colorectal cancer (CRC) and ICH are still not well known.
To investigate the clinical features and underlying pathogenesis of ICH in patients with CRC.
A retrospective review of CRC patients complicated with ICH from three centers between January 2014 and December 2020 was performed. Clinical data such as laboratory examinations, imaging features, prognosis, and underlying patho
Of 16673 identified CRC patients, 20 (0.12%) suffered from ICH. There were 13 males and 7 females, with an average age (mean ± SD) of 68.45 ± 10.66 years. Fourteen patients (70%) had distant metastases and most patients (85%) showed an elevation of one or more cancer biomarkers. The hemorrhagic lesions in 13 patients (65%) were in the intracerebral lobe. Four patients were completely dependent and 4 died within 30 days after hemorrhage. Intratumoral hemorrhage (50%) and coagulopathy (50%) accounted for the majority of hemorrhages.
Patients with ICH and CRC often have clinical features with lobar hemorrhage, distant metastases and poor prognosis. Intratumoral hemorrhage and coagu
Core Tip: The association between cancer and intracerebral hemorrhage (ICH) has long been studied, however little attention has been paid to the hemorrhagic cerebrovascular events in patients with colorectal cancer (CRC). CRC has been reported to increase the risk of ICH. The present study retrospectively analyzed the clinical data of patients with CRC and ICH, and indicated that intratumoral hemorrhage and coagulopathy were the main causes of ICH in CRC patients.