Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2021; 13(11): 1741-1754
Published online Nov 15, 2021. doi: 10.4251/wjgo.v13.i11.1741
Preventive and inhibitive effects of Yiwei Xiaoyu granules on the development and progression of spasmolytic polypeptide-expressing metaplasia lesions
Wan-Qun Chen, Feng-Liang Tian, Jin-Wei Zhang, Xiao-Jun Yang, Yan-Ping Li
Wan-Qun Chen, Feng-Liang Tian, Xiao-Jun Yang, Yan-Ping Li, Department of Gastroenterology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400000, China
Jin-Wei Zhang, Department of Dermatology and Cosmetology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400000, China
Author contributions: Yang XJ and Li YP contributed equally to this work; Chen WQ, Tian FL, Yang XJ and Li YP designed the research study; Chen WQ and Zhang JW performed the research; Tian FL and Zhang JW contributed new reagents and analytic tools; Chen WQ, Yang XJ and Li YP analyzed the data and wrote the manuscript; All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81904175; Natural Science Foundation of Chongqing, China, No. cstc2018jcyjAX0756; and Chongqing Health Planning Commission Project, No. ZY201802063 and No. 2019ZY013111.
Institutional review board statement: The study was reviewed and approved by the Chongqing Hospital of Traditional Chinese Medicine Institutional Review Board (Approval No.2019-ky-25).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Chongqing Hospital of Traditional Chinese Medicine (IACUC protocol number: [Protocol No. 2020-DWKY-01]).
Conflict-of-interest statement: The authors declared that they have no conflicts of interest in this work.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Ping Li, PhD, Professor, Department of Gastroenterology, Chongqing Hospital of Traditional Chinese Medicine, No. 6 Panxi Qizhi Road, Jiangbei District, Chongqing 400000, China. lyp20210203@163.com
Received: June 3, 2021
Peer-review started: June 3, 2021
First decision: June 30, 2021
Revised: July 10, 2021
Accepted: August 24, 2021
Article in press: August 24, 2021
Published online: November 15, 2021
Processing time: 162 Days and 3.6 Hours
Core Tip

Core Tip: We showed evidence that microRNA-7 downregulation is an early event in the cascade from metaplasia to gastric cancer and that it contributes to the establishment of an intestinal expression profile through regulation of trefoil factor 2 in both human gastric mucosa and in vivo experiments. To the best of our knowledge, we used the spasmolytic polypeptide-expressing metaplasia mouse model for the first time to reveal the effectiveness and the potential mechanism of Chinese medicine Yiwei Xiaoyu granules for the precursor of gastric adenocarcinoma.