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World J Gastrointest Oncol. Oct 15, 2021; 13(10): 1213-1228
Published online Oct 15, 2021. doi: 10.4251/wjgo.v13.i10.1213
Engineering nanotheranostic strategies for liver cancer
Lei Cao, Yu-Qin Zhu, Zhi-Xian Wu, Gao-Xiong Wang, Hong-Wei Cheng
Lei Cao, Yu-Qin Zhu, Gao-Xiong Wang, Department of Pathology, Quanzhou Women's and Children's Hospital, Quanzhou 362000, Fujian Province, China
Zhi-Xian Wu, Department of Hepatobiliary Disease, The 900th Hospital of the People’s Liberation Army Joint Service Support Force, Fuzhou 350025, Fujian Province, China
Hong-Wei Cheng, School of Public Health, Xiamen University, Xiamen 361002, Fujian Province, China
Author contributions: Cao L and Zhu YQ conducted the literature manufacture and drafted the manuscript, and contributed equally to this study; Wu ZX provided technological support and contributed to the project discussion; Wang GX and Cheng HW had equal contributions to the conceptualization of this study and authentication of the validity of the reported results.
Supported by Science and Technology Innovation Joint Fund Project of Fujian Province, No. 2019Y9044; and Science and Technology Project of Quanzhou, No. 2018Z155.
Conflict-of-interest statement: The authors declare that they have no conflicting interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Wei Cheng, MD, Research Associate, School of Public Health, Xiamen University, Xiangan South Road, Xiangan District, Xiamen 361002, Fujian Province, China. hongwei1026@hotmail.com
Received: March 22, 2021
Peer-review started: March 22, 2021
First decision: June 14, 2021
Revised: June 28, 2021
Accepted: August 12, 2021
Article in press: August 12, 2021
Published online: October 15, 2021
Processing time: 205 Days and 6.7 Hours
Core Tip

Core Tip: With the development of nanotheranostic strategies for liver cancer treatment, the efficacy of drug delivery is improved by smart nanoparticles with excellent targeting capacity. To overcome the complex tumor microenvironment, nanosystems with combined strategies of curative or palliative treatments have significant synergistic therapeutic effect against unfavorable clinical obstacles in the treatment of liver cancer.