Meta-Analysis
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2020; 12(6): 687-698
Published online Jun 15, 2020. doi: 10.4251/wjgo.v12.i6.687
Timing of surgery after neoadjuvant chemoradiotherapy affects oncologic outcomes in patients with esophageal cancer
Qi-Xin Shang, Yu-Shang Yang, Yi-Min Gu, Xiao-Xi Zeng, Han-Lu Zhang, Wei-Peng Hu, Wen-Ping Wang, Long-Qi Chen, Yong Yuan
Qi-Xin Shang, Yu-Shang Yang, Yi-Min Gu, Han-Lu Zhang, Wei-Peng Hu, Wen-Ping Wang, Long-Qi Chen, Yong Yuan, Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Xiao-Xi Zeng, West China Biomedical Big Data Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Shang QX, Chen LQ and Yuan Y designed research; Shang QX, Yang YS, Gu YM, and Zhang HL performed research; Zeng XX and Hu WP contributed new reagents or analytic tools; Shang QX, Gu YM and Wang WP analyzed data; Shang QX wrote the paper; all authors approved the final version; Shang QX and Yang YS contributed equally to this work.
Supported by the National Natural Science Foundation of China, No. 81970481; Sichuan Science and Technology Program, No. 2018HH0150 and Chengdu Science and Technology Bureau, No. 2016GH0200020HZ.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yong Yuan, MD, PhD, Associate Professor, Department of Thoracic Surgery, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, Sichuan Province, China. yongyuan@scu.edu.cn
Received: January 23, 2020
Peer-review started: January 23, 2020
First decision: March 24, 2020
Revised: April 9, 2020
Accepted: April 28, 2020
Article in press: April 28, 2020
Published online: June 15, 2020
Processing time: 144 Days and 8 Hours
Core Tip

Core tip: Esophageal cancer is one of the most common malignant tumors worldwide. Neoadjuvant chemoradiotherapy (nCRT) is increasingly used as the standard treatment for most esophageal cancer patients. However, the optimal time interval for esophagectomy after nCRT in patients with esophageal cancer has not been defined. Therefore, we conducted a meta-analysis on 12621 patients from 16 studies to evaluate whether a prolonged time interval from the end of nCRT to surgery has an effect on survival outcome in esophageal cancer patients.