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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2019; 11(4): 281-294
Published online Apr 15, 2019. doi: 10.4251/wjgo.v11.i4.281
Published online Apr 15, 2019. doi: 10.4251/wjgo.v11.i4.281
Up-regulation of tumor necrosis factor-α pathway survival genes and of the receptor TNFR2 in gastric cancer
Ana Flávia Teixeira Rossi, Júlia Cocenzo Contiero, Fernanda da Silva Manoel-Caetano, Ana Elizabete Silva, Department of Biology, São Paulo State University – UNESP, São José do Rio Preto, SP 15054-000, Brazil
Fábio Eduardo Severino, Department of Surgery and Orthopedics, Faculty of Medicine, São Paulo State University – UNESP, Botucatu, SP 18618-687, Brazil
Author contributions: Rossi AFT and Silva AE outlined the study; Rossi AFT, Contiero JC, Manoel-Caetano FS performed the experiments; Rossi AFT analyzed and interpreted the results; Severino FE built the interaction network; Rossi AFT and Silva AE drafted the manuscript and revised it; all authors approved the final version of the manuscript.
Supported by São Paulo Research Foundation-FAPESP , grants Nos. 2015/21464-0 and 2015/23392-7 ; and National Counsel of Technological and Scientific Development-CNPq , grant No. 310120/2015-2 .
Institutional review board statement: This study was approved by local Research Ethics Committee (CEP – IBILCE/UNESP, number 1.336.892).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ana Elizabete Silva, PhD, Adjunct Professor, Department of Biology, São Paulo State University - UNESP, Rua Cristóvão Colombo, 2265, São José do Rio Preto SP 15054-000, Brazil. ae.silva@unesp.br
Telephone: +55-17-32212384 Fax: +55-17-322212390
Received: January 11, 2019
Peer-review started: January 11, 2019
First decision: January 26, 2019
Revised: February 16, 2019
Accepted: February 27, 2019
Article in press: February 28, 2019
Published online: April 15, 2019
Processing time: 94 Days and 21.9 Hours
Peer-review started: January 11, 2019
First decision: January 26, 2019
Revised: February 16, 2019
Accepted: February 27, 2019
Article in press: February 28, 2019
Published online: April 15, 2019
Processing time: 94 Days and 21.9 Hours
Core Tip
Core tip: We evaluated the expression of mRNA and microRNAs (miRNAs) related to the tumor necrosis factor (TNF)-α signaling pathway in gastric cancer (GC) fresh tissues. Our study shows up-regulation of cell survival genes (TNF, TNFR2, TRADD, TRAF2, CFLIP, NFKB2, CASP8) of this signaling pathway in GC, stimulating cell growth possibly by TNFR2 and negatively controls TNFR1-mediated apoptosis by down-regulation of pro-apoptotic mediators (TNFR1 and CASP3). Furthermore, interaction network between miRNAs and mRNA investigated suggests that TNF-α signaling pathway can be regulated by the action of miRNAs, mainly miR-19a and miR-103a, which may influence tumor development. Ours findings suggest TNFR2 as a potential therapeutic target for GC.