Meta-Analysis
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2019; 11(10): 909-924
Published online Oct 15, 2019. doi: 10.4251/wjgo.v11.i10.909
Abnormally expressed circular RNAs as novel non-invasive biomarkers for hepatocellular carcinoma: A meta-analysis
Ya-Lin Jiang, Meng-Meng Shang, Shi-Zhen Dong, Yong-Chao Chang
Ya-Lin Jiang, Meng-Meng Shang, Shi-Zhen Dong, Yong-Chao Chang, Department of Clinical Laboratory, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan Province, China
Meng-Meng Shang, Department of Clinical Laboratory, The Family Planning Guidance Station of Luanchuan County, Luoyang 471500, Henan Province, China
Author contributions: Jiang YL acquired, analyzed, and interpreted the data and drafted, revised, and finally approved the article; Shang MM and Dong SZ acquired, analyzed, and interpreted the data and finally approved the article; Chang YC conceived and designed the study and critically revised and finally approved the article.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yong-Chao Chang, MD, PhD, Professor, Department of Clinical Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, No. 24, Jinghua Road, Jianxi District, Luoyang 471003, Henan Province, China. zero6666888@163.com
Telephone: +86-379-64830723 Fax: +86-379-64830723
Received: June 13, 2019
Peer-review started: June 19, 2019
First decision: July 31, 2019
Revised: August 6, 2019
Accepted: September 4, 2019
Article in press: September 4, 2019
Published online: October 15, 2019
Processing time: 126 Days and 9.3 Hours
Core Tip

Core tip: Current studies investigating the clinical significance of circular RNAs (circRNAs) in hepatocellular carcinoma (HCC) were conducted using single-center and small-scale design, and the findings were controversial. We collected and analyzed the up-to-date clinical data on the significance of circRNAs in the diagnosis and prognosis of HCC. The results indicated that circRNAs may be novel indicators for the prognosis and diagnosis of HCC.