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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2019; 11(10): 842-856
Published online Oct 15, 2019. doi: 10.4251/wjgo.v11.i10.842
Published online Oct 15, 2019. doi: 10.4251/wjgo.v11.i10.842
MicroRNA-320a suppresses tumor progression by targeting PBX3 in gastric cancer and is downregulated by DNA methylation
Yong-Shuang Li, Ying Zou, Dong-Qiu Dai, Department of Gastrointestinal Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China
Author contributions: Li YS and Zou Y contributed equally to this work and should be considered as co-first authors; Li YS and Dai DQ designed the study; Li YS and Zou Y collected and analyzed the data; Li YS and Zou Y performed the experiments; all authors contributed to writing, reviewing or revising the paper; Li YS and Dai DQ submitted the final manuscript and all authors read and approved the final version; all authors agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Supported by the Natural Science Foundation of Liaoning Province , No. 201602817 .
Institutional review board statement: Institutional review board approval of our hospital was obtained for this study.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Dong-Qiu Dai, MD, PhD, Professor, Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshan East Road, Shenyang 110032, Liaoning Province, China. daidq63@163.com
Telephone: +86-24-62043110Fax: +86-24-62043110
Received: April 23, 2019
Peer-review started: May 7, 2019
First decision: June 4, 2019
Revised: June 19, 2019
Accepted: July 26, 2019
Article in press: July 28, 2019
Published online: October 15, 2019
Processing time: 176 Days and 22.2 Hours
Peer-review started: May 7, 2019
First decision: June 4, 2019
Revised: June 19, 2019
Accepted: July 26, 2019
Article in press: July 28, 2019
Published online: October 15, 2019
Processing time: 176 Days and 22.2 Hours
Core Tip
Core tip: miRNA (miR)-320a functioned as a tumor suppressor and was downregulated in gastric cancer (GC). miR-320a overexpression suppressed proliferation, migration and invasion, and induced apoptosis through targeting Pre-B-cell leukemia homeobox 3 in GC cells. miR-320a depletion showed the opposite results. The potential mechanism of miR-320a deficiency in GC was the increased methylation level of the miR-320a promoter CpG islands.