McCarthy AJ, Chetty R. Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review. World J Gastrointest Oncol 2019; 11(1): 59-70 [PMID: 30984351 DOI: 10.4251/wjgo.v11.i1.59]
Corresponding Author of This Article
Aoife J McCarthy, MB BCh BAO BMed Sci CHAT FRCPath, Doctor, Clinical Fellow, Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, ON M5G 2C4, Canada. aoife.mccarthy@uhn.ca
Research Domain of This Article
Oncology
Article-Type of This Article
Systematic Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jan 15, 2019; 11(1): 59-70 Published online Jan 15, 2019. doi: 10.4251/wjgo.v11.i1.59
Gut-associated lymphoid tissue or so-called “dome” carcinoma of the colon: Review
Aoife J McCarthy, Runjan Chetty
Aoife J McCarthy, Runjan Chetty, Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, Toronto, ON M5G 2C4, Canada
Aoife J McCarthy, Runjan Chetty, Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5G 2C4, Canada
Author contributions: Both authors contributed to this paper.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Aoife J McCarthy, MB BCh BAO BMed Sci CHAT FRCPath, Doctor, Clinical Fellow, Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, ON M5G 2C4, Canada. aoife.mccarthy@uhn.ca
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Received: July 16, 2018 Peer-review started: July 17, 2018 First decision: August 8, 2018 Revised: September 13, 2018 Accepted: October 12, 2018 Article in press: October 12, 2018 Published online: January 15, 2019 Processing time: 183 Days and 10.5 Hours
Core Tip
Core tip: This review comprehensively presents the etiology, clinical features, macroscopic and pathological findings, and clinical significance of gut- or gastrointestinal-associated lymphoid tissue (GALT) or “dome” carcinoma of the colon. These lesions are thought to arise from the M-cells of the GALT (lymphoglandular complex) of the intestine. They have a characteristic endoscopic plaque- or “dome”-like appearance. Histologically, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, and dilated glands lined by bland columnar epithelial cells with eosinophilic cytoplasm. There have been no reports of metastatic disease or local recurrence in patients with colonic GALT/dome-type carcinomas.
