Published online May 15, 2023. doi: 10.4251/wjgo.v15.i5.787
Peer-review started: November 30, 2022
First decision: December 25, 2022
Revised: January 6, 2023
Accepted: April 7, 2023
Article in press: April 7, 2023
Published online: May 15, 2023
Gastric cancer (GC) is a common malignant tumor with high prevalence and mortality. Circular RNA (circRNA) analysis in GSE184882 has indicated that circ_0003356 shows abnormal expression in GC tissues, but the function of circ_0003356 remains unclear in GC.
To seek the prognostic biomarker and therapeutic target for GC.
In order to explore the function and mechanism of circ_0003356 in GC.
Quantitative real-time polymerase chain reaction was used to detect expression of circ_0003356. The clinical value of circ_0003356 for GC prognosis was evaluated. The role of circ_0003356 in GC was assessed via in vitro and in vivo experiments. The molecular mechanism of circ_0003356 on miR-668-3p/SOCS3 axis was validated.
Circ_0003356 expression was markedly decreased in GC tissues and cells, and it was positively associated with survival time of GC patients. Moreover, functional analyses showed that circ_0003356 overexpression inhibited malignant behaviors of GC cells via targeting the miR-668-3p/SOCS3 axis.
Circ_0003356 is lowly expressed in GC tissues and cells, displaying potential as a prognostic biomarker for GC. Circ_0003356 up-regulation represses the malignancy of GC via targeting the miR-668-3p/SOCS3 axis.
Other mechanisms of circ_0003356 in GC may be probed in future researches, and its application in treatment of GC will be extended.