Randomized Controlled Trial
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 319-333
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.319
Effects of cognitive behavior therapy combined with Baduanjin in patients with colorectal cancer
Zheng-Gen Lin, Ren-Dong Li, Fu-Lu Ai, Song Li, Xin-An Zhang
Zheng-Gen Lin, School of Social and Physical Education, Shenyang Sport University, Shenyang 110102, Liaoning Province, China
Ren-Dong Li, Physical Education Department, Shenyang University of Chemical Technology, Shenyang 110142, Liaoning Province, China
Fu-Lu Ai, Department of General Surgery (VIP Ward), Liaoning Tumor Hospital, Shenyang 110042, Liaoning Province, China
Song Li, Martial Arts and Dance Academy, Shenyang Sport University, Shenyang 110102, Liaoning Province, China
Xin-An Zhang, College of Kinesiology, Shenyang Sport University, Shenyang 110102, Liaoning Province, China
Author contributions: Lin ZG contributed to conception of the study; Li RD performed the experiments and wrote the manuscript; Ai FL contributed significantly to data analysis and manuscript preparation; Li S helped perform the data analysis with constructive discussions; Zhang XA contributed significantly to data analysis and manuscript preparation; Li S and Zhang XA contributed equally to the article and should be regarded as co-corresponding authors.
Supported by The Scientific Research Funds Project of Liaoning Education Department, No. LJC2019ST02.
Institutional review board statement: This study was approved by the Institutional Review Board of Liaoning Cancer Hospital.
Clinical trial registration statement: Clinical Trial registration was not conducted for this study.
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at zhangxa2725@163.com.
CONSORT 2010 statement: The manuscript was checked according to the CONSORT 2010.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Song Li, MSc, Additional Professor, Martial Arts and Dance Academy, Shenyang Sport University, No. 36 Jinqiansong East Road, Sujiatun District, Shenyang 110102, Liaoning Province, China. cuiluxiang@syty.edu.cn
Received: June 10, 2021
Peer-review started: June 10, 2021
First decision: July 16, 2021
Revised: July 30, 2021
Accepted: September 10, 2021
Article in press: September 10, 2021
Published online: January 15, 2022
Processing time: 214 Days and 23.1 Hours
ARTICLE HIGHLIGHTS
Research background

Patients with colorectal cancer (CRC) after chemotherapy are often accompanied with cancer-related fatigue (CRF) and cancer-related cognitive dysfunction, which seriously affects the quality of life and recovery during chemotherapy, but there is no effective treatment.

Research motivation

This study sought to find an effective treatment for cognitive impairment and cancer-related fatigue after chemotherapy for CRC, and to provide a theoretical basis and practical reference for rehabilitation of CRC patients.

Research objectives

This study aimed to explore the effects cognitive behavior therapy (CBT) combined with Baduanjin exercise on CRF, cognitive impairment, and quality of life in patients with CRC after chemotherapy.

Research methods

Patients with CRC were treated with CBT combined with Baduanjin (experimental group, n = 27) or usual care (control group, n = 28), and then the changes of cancer-related fatigue, cognitive function, quality of life, and P300 amplitude and latency were compared at baseline, 3 mo, and 6 mo.

Research results

Compared with the baseline values, the cancer-related fatigue, cognitive function, quality of life, and P300 amplitude and latency were significantly better in the experimental group at 3 mo (P < 0.01). The cancer-related fatigue, cognitive function, quality of life, and P300 amplitude and latency were significantly better in the experimental group than in the control group (experimental group vs control group at 3/6 mo; P < 0.05 or P < 0.01). The quality of life was negatively correlated with cancer-related fatigue and positively correlated with cognitive function.

Research conclusions

CBT combined with Baduanjin exercise can improve fatigue and cognitive impairment of CRC patients undergoing chemotherapy, and improve their quality of life. The quality of life of CRC patients is closely related to their CRF and cognitive level. CBT combined with exercise intervention is worth promoting in the postoperative rehabilitation of cancer patients.

Research perspectives

This study contributes to the rehabilitation of cognitive impairment and cancer-related fatigue in patients with colorectal cancer after chemotherapy. To confirm and validate the results of this study, a larger scale prospective study would be helpful.