Randomized Controlled Trial
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 319-333
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.319
Effects of cognitive behavior therapy combined with Baduanjin in patients with colorectal cancer
Zheng-Gen Lin, Ren-Dong Li, Fu-Lu Ai, Song Li, Xin-An Zhang
Zheng-Gen Lin, School of Social and Physical Education, Shenyang Sport University, Shenyang 110102, Liaoning Province, China
Ren-Dong Li, Physical Education Department, Shenyang University of Chemical Technology, Shenyang 110142, Liaoning Province, China
Fu-Lu Ai, Department of General Surgery (VIP Ward), Liaoning Tumor Hospital, Shenyang 110042, Liaoning Province, China
Song Li, Martial Arts and Dance Academy, Shenyang Sport University, Shenyang 110102, Liaoning Province, China
Xin-An Zhang, College of Kinesiology, Shenyang Sport University, Shenyang 110102, Liaoning Province, China
Author contributions: Lin ZG contributed to conception of the study; Li RD performed the experiments and wrote the manuscript; Ai FL contributed significantly to data analysis and manuscript preparation; Li S helped perform the data analysis with constructive discussions; Zhang XA contributed significantly to data analysis and manuscript preparation; Li S and Zhang XA contributed equally to the article and should be regarded as co-corresponding authors.
Supported by The Scientific Research Funds Project of Liaoning Education Department, No. LJC2019ST02.
Institutional review board statement: This study was approved by the Institutional Review Board of Liaoning Cancer Hospital.
Clinical trial registration statement: Clinical Trial registration was not conducted for this study.
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at zhangxa2725@163.com.
CONSORT 2010 statement: The manuscript was checked according to the CONSORT 2010.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Song Li, MSc, Additional Professor, Martial Arts and Dance Academy, Shenyang Sport University, No. 36 Jinqiansong East Road, Sujiatun District, Shenyang 110102, Liaoning Province, China. cuiluxiang@syty.edu.cn
Received: June 10, 2021
Peer-review started: June 10, 2021
First decision: July 16, 2021
Revised: July 30, 2021
Accepted: September 10, 2021
Article in press: September 10, 2021
Published online: January 15, 2022
Abstract
BACKGROUND

Cancer-related fatigue (CRF) is the most common concomitant symptom in the treatment of colorectal cancer (CRC). Such patients often present with subjective fatigue state accompanied by cognitive dysfunction, which seriously affects the quality of life of patients.

AIM

To explore the effects of cognitive behavior therapy (CBT) combined with Baduanjin exercise on CRF, cognitive impairment, and quality of life in patients with CRC after chemotherapy, and to provide a theoretical basis and practical reference for rehabilitation of CRC after chemotherapy.

METHODS

Fifty-five patients with CRC after radical resection and chemotherapy were randomly divided into either an experimental or a control group. The experimental group received the intervention of CBT combined with exercise intervention for 6 mo, and indicators were observed and measured at baseline, 3 mo, and 6 mo to evaluate the intervention effect.

RESULTS

Compared with the baseline values, in the experimental group 3 mo after intervention, cognitive function, quality of life score, and P300 amplitude and latency changes were significantly better (P < 0.01). Compared with the control group, at 3 mo, the experimental group had significant differences in CRF, P300 amplitude, and quality of life score (P < 0.05), as well as significant differences in P300 latency and cognitive function (P < 0.01). Compared with the control group, at 6 mo, CRF, P300 amplitude, P300 latency, cognitive function and quality of life score were further improved in the experimental group, with significant differences (P < 0.01). The total score of CRF and the scores of each dimension were negatively correlated with quality of life (P < 0.05), while the total score of cognitive impairment and the scores of each dimension were positively correlated with quality of life (P < 0.05).

CONCLUSION

CBT combined with body-building Baduanjin exercise can improve CRF and cognitive impairment in CRC patients after chemotherapy, and improve their quality of life.

Keywords: Colorectal cancer, Cognitive behavior therapy, Baduanjin exercise, Cancer-related fatigue, Cognitive function, Quality of life

Core Tip: Cognitive behavior therapy combined with body-building Baduanjin exercise can improve cancer-induced fatigue and cognitive impairment in colorectal cancer patients after chemotherapy, and improve their quality of life. The quality of life of colorectal cancer patients may be related to cancer-induced fatigue and cognitive level. Cognitive behavior therapy combined with exercise intervention deserves to be promoted in cancer patients.