Wei X, Feng XP, Wang LY, Huang YQ, Liang LL, Mo XQ, Wei HY. Improved method for inducing chronic atrophic gastritis in mice. World J Gastrointest Oncol 2019; 11(12): 1115-1125 [PMID: 31908717 DOI: 10.4251/wjgo.v11.i12.1115]
Corresponding Author of This Article
Yan-Qiang Huang, MD, PhD, Professor, Breeding Base of Microbial Infection Key Laboratory in the West Guangxi, Youjiang Medical University for Nationalities, No. 98, Countryside Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. hyq77615@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xian Wei, Xue-Ping Feng, Lu-Yao Wang, Yan-Qiang Huang, Ling-Ling Liang, Xiao-Qiang Mo, Hong-Yu Wei, Breeding Base of Microbial Infection Key Laboratory in the West Guangxi, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China.
Author contributions: Wei X and Feng XP performed the research and contributed equally to this work; Wang LY, Liang LL, Mo XQ, and Wei HY analyzed the data; Huang YQ designed the research and analyzed the data; all authors drafted the article, made critical revisions related to the intellectual content of the manuscript, and approved the final version of the article to be published.
Supported byNational Natural Science Foundation of China, No. 31460023; Science Research and Technology Development Project of Guangxi, No. 1598025-33.
Institutional review board statement: All specimens from the patients were obtained after informed consent and ethical permission were obtained for participation in the study.
Conflict-of-interest statement: The authors report no relevant conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yan-Qiang Huang, MD, PhD, Professor, Breeding Base of Microbial Infection Key Laboratory in the West Guangxi, Youjiang Medical University for Nationalities, No. 98, Countryside Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. hyq77615@163.com
Telephone: +86-776-2849490 Fax: +86-776-2853272
Received: May 16, 2019 Peer-review started: May 21, 2019 First decision: July 31, 2019 Revised: August 5, 2019 Accepted: October 1, 2019 Article in press: October 1, 2019 Published online: December 15, 2019 Processing time: 208 Days and 17.2 Hours
ARTICLE HIGHLIGHTS
Research background
Chronic atrophic gastritis (CAG) is a precancerous lesion of gastric cancer. If it is effectively treated, GC will be prevented. So the prevention and treatment of CAG are very important. It needs a good animal model, which can provide etiological research and screening of therapeutic drugs. It is an important tool for studying CAG.
Research motivation
Current animal models of chronic atrophic gastritis are not ideal, long cycle, high cost, difficult to operate, and unstable, so better animal models are needed.
Research objectives
To construct a more rapid, safe, stable and efficient chronic atrophic gastritis model with mice.
Research methods
The mice selected for this method were six-week-old Kunming mice, and Helicobacter pylori, N-methyl-N'-nitroguanidine, and ammonia water were combined to develop a CAG model.
Research results
The method showed slight CAG at the 90th day and moderate CAG at the 120th day.
Research conclusions
The method presented here is more rapid, safe, stable, and efficient.
Research perspectives
Starting from the etiology of chronic atrophic gastritis, the course of the disease is simulated to explore a simple, fast, convenient, and stable method of modelling.
