Scientometrics
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2024; 16(5): 2200-2218
Published online May 15, 2024. doi: 10.4251/wjgo.v16.i5.2200
Hotspots and trends of risk factors in gastric cancer: A visualization and bibliometric analysis
Meng Li, Ning Gao, Shao-Li Wang, Yu-Feng Guo, Zhen Liu
Meng Li, Shao-Li Wang, Zhen Liu, Department of Gastroenterology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Ning Gao, Yu-Feng Guo, Department of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Co-first authors: Meng Li and Ning Gao.
Co-corresponding authors: Yu-Feng Guo and Zhen Liu.
Author contributions: Guo YF and Liu Z contributed to the conception and design of the study; Wang SL is responsible for literature searching, data collection; Li M and Gao N are responsible for statistical analysis and charting; Li M and Gao N was drafted and revised the manuscript. All authors were involved in the critical review of the results and have contributed to, read, and approved the final manuscript. Liu Z and Guo YF coordinated the design and facilities for this study, provided multiple support in terms of personnel, materials and methods for the conduct of this study, and were responsible for all correspondence with the editorial board and readers. Therefore, Liu Z and Guo YF are listed as co-corresponding authors as the leaders of this study. Li M and Gao N were the main drafters and revisers of this manuscript, as well as assisting other authors with data organization, processing, and analysis. Their contributions to this study are highly valued by other researchers. Therefore, Li M and Gao N are listed as co-first authors.
Supported by Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences, No. CI2023C015YL; and National Natural Science Foundation of China, No. 82174352.
Conflict-of-interest statement: Authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Meng Li, PhD, Doctor, Department of Gastroenterology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange Street, Xicheng District, Beijing 100053, China. zyxyjslm@163.com
Received: January 19, 2024
Peer-review started: January 19, 2024
First decision: January 27, 2024
Revised: February 8, 2024
Accepted: March 11, 2024
Article in press: March 11, 2024
Published online: May 15, 2024
Processing time: 111 Days and 6.1 Hours
Abstract
BACKGROUND

The lack of specific symptoms of gastric cancer (GC) causes great challenges in its early diagnosis. Thus it is essential to identify the risk factors for early diagnosis and treatment of GC and to improve the survival rates.

AIM

To assist physicians in identifying changes in the output of publications and research hotspots related to risk factors for GC, constructing a list of key risk factors, and providing a reference for early identification of patients at high risk for GC.

METHODS

Research articles on risk factors for GC were searched in the Web of Science core collection, and relevant information was extracted after screening. The literature was analyzed using Microsoft Excel 2019, CiteSpace V, and VOSviewer 1.6.18.

RESULTS

A total of 2514 papers from 72 countries and 2507 research institutions were retrieved. China (n = 1061), National Cancer Center (n = 138), and Shoichiro Tsugane (n = 36) were the most productive country, institution, or author, respectively. The research hotspots in the study of risk factors for GC are summarized in four areas, namely: Helicobacter pylori (H. pylori) infection, single nucleotide polymorphism, bio-diagnostic markers, and GC risk prediction models.

CONCLUSION

In this study, we found that H. pylori infection is the most significant risk factor for GC; single-nucleotide polymorphism (SNP) is the most dominant genetic factor for GC; bio-diagnostic markers are the most promising diagnostic modality for GC. GC risk prediction models are the latest current research hotspot. We conclude that the most important risk factors for the development of GC are H. pylori infection, SNP, smoking, diet, and alcohol.

Keywords: Gastric cancer; Risk factor; Bibliometric; Research hotspots; VOSviewer

Core Tip: In this study, we searched and organized relevant articles in the field of risk factors for gastric cancer (GC) and carried out a bibliometric analysis. In this manuscript, we summarize the current state of development in the field, produce a table of key risk factors in GC, and achieve a prediction of future research trends.