Published online Sep 15, 2023. doi: 10.4251/wjgo.v15.i9.1636
Peer-review started: July 4, 2023
First decision: July 19, 2023
Revised: July 25, 2023
Accepted: August 8, 2023
Article in press: August 8, 2023
Published online: September 15, 2023
Recurrence is the major challenge facing endoscopic submucosal dissection (ESD)-based treatment therapies for early gastric cancer (EGC). Urgent development of simple and easy surveillance approaches will enhance clinical treatment of the disease.
To explore the role of computed tomography (CT) recurrence in evaluating EGC after ESD treatment.
We retrospectively recruited patients from our endoscopy department, between January 2002 and December 2015, and analyzed their basic characteristics, including symptoms, CT results, and results of endoscopy with biopsy, among others.
Among a total of 2150 patients EGC patients surveyed, 1362 met our inclusion and exclusion criteria and were therefore enrolled in our study. The cohort’s sensitivity of CT for recurrent GC and specificity were 44.22% and 43.86%, respectively, with negative and positive predictive values of 40.15% (275/685) and 48.01% (325/677), respectively. The area under the curve of arterial and venous CT values for recurrent EGC were 0.545, and 0.604, respectively. Receiver operating characteristic curve revealed no statistically significant differences between arterial and venous CT values for recurrent EGC.
Enhanced CT has superior diagnostic efficacy, but less accuracy, compared to gold standard techniques in patients with recurrent EGC.
Core Tip: Development of a simple and easy approach to detect recurrence of early gastric cancer (EGC) treated with endoscopic mucosal exfoliation is imperative to effective clinical therapy. Here, we report the feasibility of multi-slice spiral computed tomography (CT), a quick and convenient auxiliary examination with sensitivity and specificity values of 44.22% and 43.86%, respectively, in evaluating arterial and venous CT values for recurrent EGC. Area under the curve value of arterial and venous CT values for recurrent EGC respectively were 0.55 and 0.60, indicating that enhanced CT can accurately predict EGC, although with low accuracy.