Kudchadkar S, Ahmed S, Mukherjee T, Sagar J. Current guidelines in the surgical management of hereditary colorectal cancers. World J Gastrointest Oncol 2022; 14(4): 833-841 [PMID: 35582097 DOI: 10.4251/wjgo.v14.i4.833]
Corresponding Author of This Article
Jayesh Sagar, FRCS (Ed), MBBS, MD, MS, Chief Doctor, Surgeon, Surgical Oncologist, Department of Colorectal Surgery, Luton & Dunstable University Hospital NHS Foundation Trust, Lewsey Road, Luton LU4 0DZ, United Kingdom. jayesh.sagar@ldh.nhs.uk
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Shantata Kudchadkar, Safia Ahmed, Tanmoy Mukherjee, Jayesh Sagar, Department of Colorectal Surgery, Luton & Dunstable University Hospital NHS Foundation Trust, Luton LU4 0DZ, United Kingdom
Author contributions: Kudchadkar S collected data and prepared the manuscript; Ahmed S and Mukherjee T analysed data; Sagar J reviewed and edited the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jayesh Sagar, FRCS (Ed), MBBS, MD, MS, Chief Doctor, Surgeon, Surgical Oncologist, Department of Colorectal Surgery, Luton & Dunstable University Hospital NHS Foundation Trust, Lewsey Road, Luton LU4 0DZ, United Kingdom. jayesh.sagar@ldh.nhs.uk
Received: July 25, 2021 Peer-review started: July 25, 2021 First decision: October 3, 2021 Revised: October 16, 2021 Accepted: March 4, 2022 Article in press: March 4, 2022 Published online: April 15, 2022
Abstract
Incidence of colorectal cancer (CRC) is on rise. While approximately 70% of all CRC cases are sporadic in nature, 20%-25% have familial aggregation and only < 5% is hereditary in origin. Identification of individuals with hereditary predilection for CRC is critical, as it has an impact on their overall surgical management including surgical timing, approach & technique and determines the role of prophylactic surgery and outcome. This review highlights the concept of hereditary CRC, provides insight into its molecular basis, possibility of its application into clinical practice and emphasizes the current treatment strategies with surgical management, based on the available international guidelines.
Core Tip: Hereditary colorectal cancer, although contributes to only a small number of cases compared to sporadic cases, is significant due to its potential of carriage and also due to complexity in its management, considering possible involvement of cancers of other organs. We aim to look at the available evidence-based guidelines across the globe and attempt to summarize them together for readers to apply with simplicity.
