Published online Jul 15, 2021. doi: 10.4251/wjgo.v13.i7.732
Peer-review started: January 4, 2021
First decision: May 3, 2021
Revised: May 16, 2021
Accepted: June 25, 2021
Article in press: June 25, 2021
Published online: July 15, 2021
For well-selected patients and procedures, laparoscopic liver resection (LLR) has become the gold standard for the treatment of colorectal liver metastases (CRLM) when performed in specialized centers. However, little is currently known concerning patient-related and peri-operative factors that could play a role in survival outcomes associated with LLR for CRLM.
To provide an extensive summary of reported outcomes and prognostic factors associated with LLR for CRLM.
A systematic search was performed in PubMed, EMBASE, Web of Science and the Cochrane Library using the keywords “colorectal liver metastases”, “laparo
Out of 1064 articles retrieved by means of a systematic and grey literature search, 77 were included for qualitative analysis. Seventy-two research papers provided data concerning outcomes of LLR for CRLM. Fourteen papers were eligible for extraction of data concerning prognostic factors affecting survival outcomes. Qualitative analysis of the collected data showed that LLR for CRLM is safe, feasible and provides oncological efficiency. Multiple research groups have reported on the short-term advantages of LLR compared to open procedures. The obtained results accounted for minor LLR, as well as major LLR, simultaneous laparoscopic colorectal and liver resection, LLR of posterosuperior segments, two-stage hepatectomy and repeat LLR for CRLM. Few research groups so far have studied prognostic factors affecting long-term outcomes of LLR for CRLM.
In experienced hands, LLR for CRLM provides good short- and long-term outcomes, independent of the complexity of the procedure.
Core Tip: Laparoscopic liver surgery has been widely adopted over the last few years. Meanwhile, laparoscopic liver resection (LLR) has become the gold standard for the treatment of colorectal liver metastases (CRLM) in specialized centers and for well-selected patients and procedures. However, little is known concerning patient-related and peri-operative factors potentially playing a role in survival outcomes associated with LLR for CRLM. The aim of this systematic review is to provide an extensive summary of reported outcomes and prognostic factors associated with LLR for CRLM.