Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2016; 8(12): 399-427
Published online Dec 26, 2016. doi: 10.4252/wjsc.v8.i12.399
Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment
Antonin Bukovsky
Antonin Bukovsky, Laboratory of Reproductive Biology BIOCEV, Institute of Biotechnology Czech Academy of Sciences, 25250 Vestec, Czech Republic
Author contributions: Bukovsky A solely contributed to this paper.
Conflict-of-interest statement: The author declares no conflict of interest for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Antonin Bukovsky, MD, PhD, DSc, Professor, Laboratory of Reproductive Biology BIOCEV, Institute of Biotechnology Czech Academy of Sciences, Národní 3, 117 20 Praha 1, 25250 Vestec, Czech Republic.
Telephone: +865-964-0602
Received: June 12, 2016
Peer-review started: June 17, 2016
First decision: July 11, 2016
Revised: August 19, 2016
Accepted: September 21, 2016
Article in press: September 22, 2016
Published online: December 26, 2016
Core Tip

Core tip: Currently, there are little possibilities to treat age-associated disorders, since the morphostasis of normal tissues and its alteration with age advancement remain poorly understood. The components of the immune system, beside immunity, exhibit an important morphostatic function in the regulation of tissue physiology and regeneration as participants in the tissue morphostasis management. Age-induced immune system decline is accompanied by gonadal infertility and growing incidence of age-associated diseases and cancers. Utilization of young blood can alleviate aging, and a novel simple elaborated immunotherapy can cause regression of advanced cancers without a need of the debulking surgery and/or exhaustive chemotherapy.