Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2016; 8(12): 399-427
Published online Dec 26, 2016. doi: 10.4252/wjsc.v8.i12.399
Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment
Antonin Bukovsky
Antonin Bukovsky, Laboratory of Reproductive Biology BIOCEV, Institute of Biotechnology Czech Academy of Sciences, 25250 Vestec, Czech Republic
Author contributions: Bukovsky A solely contributed to this paper.
Conflict-of-interest statement: The author declares no conflict of interest for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Antonin Bukovsky, MD, PhD, DSc, Professor, Laboratory of Reproductive Biology BIOCEV, Institute of Biotechnology Czech Academy of Sciences, Národní 3, 117 20 Praha 1, 25250 Vestec, Czech Republic.
Telephone: +865-964-0602
Received: June 12, 2016
Peer-review started: June 17, 2016
First decision: July 11, 2016
Revised: August 19, 2016
Accepted: September 21, 2016
Article in press: September 22, 2016
Published online: December 26, 2016

Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo. Lack of proper differentiation of tissue cells by TCS causes either tissue underdevelopment, e.g., muscular dystrophy, or degenerative functional failures, e.g., type 1 diabetes and age-associated diseases. With the gradual IMS regression after 35 years of age the gonadal infertility develops, followed by a growing incidence of age-associated diseases and cancers. Without restoring an altered TCS function in a degenerative disease, the implantation of tissue-specific stem cells alone by regenerative medicine can not be successful. Transfused young blood could temporarily restore fertility to enable parenthood. The young blood could also temporarily alleviate aging diseases, and this can be extended by substances inducing IMS regeneration, like the honey bee propolis. The local and/or systemic use of honey bee propolis stopped hair and teeth loss, regressed varicose veins, improved altered hearing, and lowered high blood pressure and sugar levels. Complete regression of stage IV ovarian cancer with liver metastases after a simple elaborated immunotherapy is also reported.

Keywords: Blood mononuclear cells, Age-associated diseases, Infertility treatment, Regenerative medicine, Transfusion morphostatic treatment, Stem cells, Tissue control system, Immune system, Tissue morphostasis, Cancer immunotherapy

Core tip: Currently, there are little possibilities to treat age-associated disorders, since the morphostasis of normal tissues and its alteration with age advancement remain poorly understood. The components of the immune system, beside immunity, exhibit an important morphostatic function in the regulation of tissue physiology and regeneration as participants in the tissue morphostasis management. Age-induced immune system decline is accompanied by gonadal infertility and growing incidence of age-associated diseases and cancers. Utilization of young blood can alleviate aging, and a novel simple elaborated immunotherapy can cause regression of advanced cancers without a need of the debulking surgery and/or exhaustive chemotherapy.