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World J Stem Cells. Nov 26, 2014; 6(5): 637-643
Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.637
Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.637
Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration
Bruno C Huber, Ulrich Grabmaier, Stefan Brunner, Department of Internal Medicine I, Ludwig-Maximilians-University, Campus Grosshadern, D-81377 Munich, Germany
Author contributions: Huber BC and Brunner S wrote the manuscript; Grabmaier U supervised the paper.
Correspondence to: Dr. med. Stefan Brunner, Department of Internal Medcine I, Ludwig-Maximilians-University, Campus Grosshadern, Marchioninistr. 15, D-81377 Munich, Germany. stefan.brunner@med.uni-muenchen.de
Telephone: +49-89-440076074 Fax: +49-89-440076100
Received: July 22, 2014
Revised: September 5, 2014
Accepted: September 17, 2014
Published online: November 26, 2014
Processing time: 67 Days and 16.6 Hours
Revised: September 5, 2014
Accepted: September 17, 2014
Published online: November 26, 2014
Processing time: 67 Days and 16.6 Hours
Core Tip
Core tip: Parathyroid hormone (PTH) is the principal regulator of calcium homeostasis in the human body and controls bone metabolism. Besides to its physiological role in bone remodelling PTH has been demonstrated to influence and expand the bone marrow stem cell niche as well as to induce mobilization of progenitor cells from the bone marrow into the bloodstream. This novel function of PTH on modulating the activity of the stem cell niche in the bone marrow as well as on mobilization and regeneration of bone marrow-derived progenitor cells offers new therapeutic options in bone marrow and stem cell transplantation as well as in the field of ischemic disorders.