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World J Stem Cells. Nov 26, 2014; 6(5): 637-643
Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.637
Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration
Bruno C Huber, Ulrich Grabmaier, Stefan Brunner
Bruno C Huber, Ulrich Grabmaier, Stefan Brunner, Department of Internal Medicine I, Ludwig-Maximilians-University, Campus Grosshadern, D-81377 Munich, Germany
Author contributions: Huber BC and Brunner S wrote the manuscript; Grabmaier U supervised the paper.
Correspondence to: Dr. med. Stefan Brunner, Department of Internal Medcine I, Ludwig-Maximilians-University, Campus Grosshadern, Marchioninistr. 15, D-81377 Munich, Germany. stefan.brunner@med.uni-muenchen.de
Telephone: +49-89-440076074 Fax: +49-89-440076100
Received: July 22, 2014
Revised: September 5, 2014
Accepted: September 17, 2014
Published online: November 26, 2014
Processing time: 67 Days and 16.6 Hours
Abstract

Parathyroid hormone (PTH) is well-known as the principal regulator of calcium homeostasis in the human body and controls bone metabolism via actions on the survival and activation of osteoblasts. The intermittent administration of PTH has been shown to stimulate bone production in mice and men and therefore PTH administration has been recently approved for the treatment of osteoporosis. Besides to its physiological role in bone remodelling PTH has been demonstrated to influence and expand the bone marrow stem cell niche where hematopoietic stem cells, capable of both self-renewal and differentiation, reside. Moreover, intermittent PTH treatment is capable to induce mobilization of progenitor cells from the bone marrow into the bloodstream. This novel function of PTH on modulating the activity of the stem cell niche in the bone marrow as well as on mobilization and regeneration of bone marrow-derived stem cells offers new therapeutic options in bone marrow and stem cell transplantation as well as in the field of ischemic disorders.

Keywords: Parathyroid hormone, Stem cells, Bone marrow, Mobilization, Migration

Core tip: Parathyroid hormone (PTH) is the principal regulator of calcium homeostasis in the human body and controls bone metabolism. Besides to its physiological role in bone remodelling PTH has been demonstrated to influence and expand the bone marrow stem cell niche as well as to induce mobilization of progenitor cells from the bone marrow into the bloodstream. This novel function of PTH on modulating the activity of the stem cell niche in the bone marrow as well as on mobilization and regeneration of bone marrow-derived progenitor cells offers new therapeutic options in bone marrow and stem cell transplantation as well as in the field of ischemic disorders.