Understanding and controlling the variables for advanced cell therapy

doi:10.4252/wjsc.v16.i8.784

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Aug 26, 2024 (publication date) through Aug 26, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Aug 26, 2024; 16(8): 784-798
Published online Aug 26, 2024. doi: 10.4252/wjsc.v16.i8.784

Understanding and controlling the variables for advanced cell therapy

Naveen Jeyaraman, Sandeep Shrivastava, VR Ravi, Arulkumar Nallakumarasamy, Aditya Pundkar, Madhan Jeyaraman

Naveen Jeyaraman, Arulkumar Nallakumarasamy, Department of Orthopaedics, Datta Meghe Institute of Higher Education and Research, Wardha 442004, Maharashtra, India

Naveen Jeyaraman, VR Ravi, Arulkumar Nallakumarasamy, Madhan Jeyaraman, Department of Regenerative Medicine, Mother Cell Regenerative Centre, Tiruchirappalli 620017, Tamil Nadu, India

Sandeep Shrivastava, Aditya Pundkar, Department of Orthopaedics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha 442004, Maharashtra, India

Madhan Jeyaraman, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India

Author contributions: Jeyaraman N designed the research; Jeyaraman N and Nallakumarasamy A analyzed the articles for performing the review and wrote the manuscript; Shrivastava S, Ravi VR, Pundkar A, and Jeyaraman M finalized the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Madhan Jeyaraman, MS, PhD, Assistant Professor, Research Associate, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India.madhanjeyaraman@gmail.com

Received: January 21, 2024
Revised: June 13, 2024
Accepted: July 25, 2024
Published online: August 26, 2024
Processing time: 217 Days and 14.5 Hours

Core Tip

Core Tip: Stromal vascular fraction isolation is essential for extracting mesenchymal stromal cells (MSCs) in regenerative medicine. Optimizing this process requires improved liposuction techniques, immediate processing, precise enzymatic digestion, and efficient filtration and centrifugation. Quality control is verified through flow cytometry to ensure cell viability and purity. The necessity for standardized MSC isolation protocols is emphasized to ensure reproducibility and clinical success.