Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2023; 15(9): 947-959
Published online Sep 26, 2023. doi: 10.4252/wjsc.v15.i9.947
Enhanced wound healing and hemostasis with exosome-loaded gelatin sponges from human umbilical cord mesenchymal stem cells
Xin-Mei Hu, Can-Can Wang, Yu Xiao, Peng Jiang, Yu Liu, Zhong-Quan Qi
Xin-Mei Hu, Can-Can Wang, Yu Xiao, Peng Jiang, Yu Liu, Zhong-Quan Qi, Medical College, Guangxi University, Nanning 530004, Guangxi Zhuang Autonomous Region, China
Author contributions: Qi ZQ and Hu XM contributed to the study conception and design; Hu XM, Wang CC, and Xiao Y contributed to data collection, analysis, and interpretation; Hu XM contributed to manuscript writing; Hu XM, Wang CC, Xiao Y, Jiang P, and Liu Y performed the animal experiments; Qi ZQ, Hu XM, and Xiao Y contributed to the conception, design, financial support, and final approval of the manuscript; and all the authors have read and approved the final manuscript.
Supported by the National Key R&D Program of China, No. 2018YFA0108304; the National Natural Science Foundation of China, No. 81771721 and 81971505; and the Innovation Project of Guangxi Graduate Education, No. YCBZ2022004 and YCBZ2022045.
Institutional animal care and use committee statement: All of the experimental procedures involving animals were reviewed and approved by the Ethics Committee of Guangxi University, Nanning, China (No. GXU-2021-1000).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Zhong-Quan Qi, MD, PhD, Professor, Medical College, Guangxi University, No. 100 Daxuedong Road, Nanning 530004, Guangxi Zhuang Autonomous Region, China.
Received: August 14, 2023
Peer-review started: August 14, 2023
First decision: August 22, 2023
Revised: August 31, 2023
Accepted: September 14, 2023
Article in press: September 14, 2023
Published online: September 26, 2023
Core Tip

Core Tip: In this study, we loaded exosomes derived from human umbilical cord mesenchymal stem cells onto a gelatin sponge, a common hemostatic substance in clinics, to stop bleeding and promote wound healing. The fabricated material appears relatively safe, provides better hemostatic activity than gelatin sponge alone, and promotes good wound healing.