Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2023; 15(7): 768-780
Published online Jul 26, 2023. doi: 10.4252/wjsc.v15.i7.768
Injectable hydrogel made from antler mesenchyme matrix for regenerative wound healing via creating a fetal-like niche
Guo-Kun Zhang, Jing Ren, Ji-Ping Li, Dong-Xu Wang, Sheng-Nan Wang, Li-Yan Shi, Chun-Yi Li
Guo-Kun Zhang, Jing Ren, Ji-Ping Li, Dong-Xu Wang, Sheng-Nan Wang, Chun-Yi Li, Institute of Antler Science and Product Technology, Changchun Sci-Tech University, Changchun 130600, Jilin Province, China
Jing Ren, Chun-Yi Li, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, Jilin Province, China
Li-Yan Shi, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China
Author contributions: Li CY and Zhang GK designed and supervised the research; Zhang GK, Ren J, and Li JP performed the research and analyzed the data; Wang DX and Zhang GK contributed to animal experiments; Ren J contributed to histopathological experiments; Li JP and Wang SN contributed to cell experiments; Zhang GK, Shi LY, and Li CY wrote and edited the paper; and all authors read and approved the final manuscript.
Supported by the Natural Science Foundation of Jilin Province, No. YDZJ202301ZYTS508; National Natural Science Foundation of China, No. U20A20403; Doctoral Research Start-Up Fund of Changchun Sci-Tech University, No. 202303; Young Scientific and Technological Talents Support Project of Jilin Province, No. QT202203; and Strategic Research and Consulting Project of Chinese Academy of Engineering, No. JL2022-05.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Animal Ethics Committee of Changchun Sci-Tech University (Approval No. CKARI2020012).
Conflict-of-interest statement: The authors declare no competing interests.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Yi Li, PhD, Professor, Institute of Antler Science and Product Technology, Changchun Sci-Tech University, No. 1345 Pudong Road, Changchun 130600, Jilin Province, China. lichunyi1959@163.com
Received: April 28, 2023
Peer-review started: April 28, 2023
First decision: June 7, 2023
Revised: June 9, 2023
Accepted: July 11, 2023
Article in press: July 11, 2023
Published online: July 26, 2023
Processing time: 87 Days and 22.1 Hours
Core Tip

Core Tip: Our study developed an injectable hydrogel made from antler reserve mesenchyme (a tissue suitable for stem cells) matrix for the regenerative repair of full-thickness cutaneous wounds. Moreover, we uncovered the molecular mechanism of the hydrogels in promoting regenerative wound healing, and thus pave the way for HARM to be developed for the clinic use.