Published online Jul 26, 2023. doi: 10.4252/wjsc.v15.i7.768
Peer-review started: April 28, 2023
First decision: June 7, 2023
Revised: June 9, 2023
Accepted: July 11, 2023
Article in press: July 11, 2023
Published online: July 26, 2023
Processing time: 87 Days and 22.1 Hours
It believes that hydrogels from the antler reserve mesenchyme matrix (HARM) may have clinical benefits for stimulating regenerative wound healing, especially those large cutaneous wounds caused by burns, scalds, or machinery.
This study prepared a new injectable hydrogel from antler reserve mesenchyme (RM) for regenerative wound healing via creating a fetal-like niche.
HARM was successfully prepared from antler RM. Through a full-thickness rat model, it was found that HARM improved the regeneration of cutaneous appendages and blood vessels and reduced the aggregation of disorganized collagen fiber, which may be achieved via creating a fetal-like niche at the wound site.
The HARM was prepared via enzymatic solubilization with pepsin. Then the therapeutic effects of HARM on a full-thickness cutaneous wound healing rat mode were investigated.
To develop an injectable hydrogel made from antler RM matrix for the regenerative repair of full-thickness cutaneous wounds, which may have clinical benefits for stimulating regenerative wound healing, especially those large cutaneous wounds caused by burns, scalds, or machinery.
Deer antlers are the only mammalian organ that can fully regenerate after being lost. Antler regeneration begins with regenerative healing of the wounds left after the previous antler casting. Studies show that this regenerative wound healing depends entirely on the adjacent pedicle periosteum (PP) or the PP-derived RM.
Scarring in wound healing is still a challenge in the clinic, where the goal is regeneration. Keeping the cells that regenerate the injured tissues in the optimum environment may be a practical approach to induce cutaneous regeneration and prevent abnormal scar formation. Although many approaches, such as synthetic hydrogels or extracellular matrix hydrogels, have been evaluated to improve the environment during wound healing, the outcomes have been unsatisfactory.