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World J Stem Cells. Jun 26, 2023; 15(6): 561-575
Published online Jun 26, 2023. doi: 10.4252/wjsc.v15.i6.561
Potential regulatory effects of stem cell exosomes on inflammatory response in ischemic stroke treatment
Na Chen, Yan-Lin Wang, Hui-Fang Sun, Zhuo-Ya Wang, Qi Zhang, Fei-Yan Fan, Yu-Cheng Ma, Fei-Xiang Liu, Yun-Ke Zhang
Na Chen, Fei-Yan Fan, Yu-Cheng Ma, First School of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China
Yan-Lin Wang, Hui-Fang Sun, Zhuo-Ya Wang, Qi Zhang, Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Fei-Xiang Liu, Yun-Ke Zhang, Department of Neurology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China
Yun-Ke Zhang, School of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450008, Henan Province, China
Author contributions: Chen N drafted the manuscript; Wang YL, Sun HF, Wang ZY, and Zhang Q reviewed the literature, and designed and revised the manuscript; Fan FY, Liu FX, and Ma YC generated the graphs; Zhang YK guided the construction of the manuscript; all the authors have read and approved the manuscript.
Supported by the National Natural Science Foundation of China, No. 81974564 and No. 82104730; the Zhongyuan Science and Technology Innovation Leading Talent Project, No. 224200510027; the National Natural Science Foundation of China, No. 82001973; the Youth Project Co-established by Henan Province and a Ministry grant, No. SBGJ2020003017; and the Health Science and Technology Innovation Excellent Youth Training Project in Henan Province, No. YXKC2020057.
Conflict-of-interest statement: The authors declare no conflict of interest. The funding body played no role in the design of the study; collection, analysis, and interpretation of data; or in writing the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Ke Zhang, PhD, Doctor, School of Rehabilitation Medicine, Henan University of Chinese Medicine, No. 156 Jinshui East Road, Zhengdong New District, Zhengzhou 450008, Henan Province, China. henanzyk@126.com
Received: January 7, 2023
Peer-review started: January 7, 2023
First decision: April 10, 2023
Revised: April 22, 2023
Accepted: May 16, 2023
Article in press: May 16, 2023
Published online: June 26, 2023
Processing time: 170 Days and 11.8 Hours
Core Tip

Core Tip: Mesenchymal stem cell-derived exosome (MSC-Exos) transplantation is a novel treatment method for ischemic stroke that exhibits certain achievements in trials. Here, we review the strategies developed for MSC-Exos in the neuroinflammatory response of patients with stroke and provide potential therapeutic targets. These methods provide new insights for the future clinical application of MSC-Exos in the treatment of ischemic stroke.