Exosomes from circ-Astn1-modified adipose-derived mesenchymal stem cells enhance wound healing through miR-138-5p/SIRT1/FOXO1 axis regulation
Zhi Wang, Cheng Feng, Hao Liu, Tian Meng, Wei-Qing Huang, Ke-Xin Song, You-Bin Wang, Department of Plastic and Cosmetic Surgery, Peking Union Medical College Hospital, Beijing 100730, China
Author contributions: Wang Z and Wang YB designed the project and drafted the paper based on feedback from the other authors; Feng C, Liu H, and Meng T performed all experiments and analyses; Huang WQ and Song KX took part in the analyses and draft revision.
Supported by The Beijing Municipal Natural Science Foundation, No. 7192160.
Institutional animal care and use committee statement: The Animal Care and Use Committee of Peking Union Medical College Hospital approved the investigation protocol (No: XHDW-2020-01). We carried out all postoperative animal care along with surgical interventions following the NIH Guide for Care and Use of Laboratory Animals. All surgery and euthanasia were performed under sodium pentobarbital anesthesia (30 mg/kg) by intraperitoneal injection, and all efforts were made to minimize suffering.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The datasets used or/and analyzed during the current study are available from the corresponding author on reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi Wang, MD, Doctor, Department of Plastic and Cosmetic Surgery, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. email@example.com
Received: June 13, 2022
Peer-review started: June 13, 2022
First decision: June 23, 2022
Revised: July 5, 2022
Accepted: September 9, 2022
Article in press: September 9, 2022
Published online: May 26, 2023