Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2023; 15(5): 342-353
Published online May 26, 2023. doi: 10.4252/wjsc.v15.i5.342
Advancements in adipose-derived stem cell therapy for skin fibrosis
Yu-Xin Liu, Jia-Ming Sun, Chia-Kang Ho, Ya Gao, Dong-Sheng Wen, Yang-Dan Liu, Lu Huang, Yi-Fan Zhang
Yu-Xin Liu, Jia-Ming Sun, Chia-Kang Ho, Ya Gao, Dong-Sheng Wen, Yang-Dan Liu, Lu Huang, Yi-Fan Zhang, Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai 200011, China
Author contributions: Liu YX and Sun JM wrote the manuscript; Liu YX, Sun JM, Liu YD, Wen DS and Huang L contributed significantly to manuscript preparation; Liu YX and Sun JM wrote the manuscript; Sun JM contributed to data presentation; Ho CK, Gao Y and Zhang YF revised the manuscript; All authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81772103 and No. 82172234; and Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by Science and Technology Commission of Shanghai Municipality, China, No. 22MC1940300.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Fan Zhang, MD, PhD, Associate Professor, Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, No. 639 Zhizaoju Road, Shanghai 200011, China. zhangyifan82@126.com
Received: December 28, 2022
Peer-review started: December 28, 2022
First decision: March 10, 2023
Revised: March 30, 2023
Accepted: April 13, 2023
Article in press: April 13, 2023
Published online: May 26, 2023
Core Tip

Core Tip: Pathological scarring and scleroderma are the most common conditions of skin fibrosis with high medical needs and poor therapeutic effects. Adipose-derived stem cell (ASC) therapy has emerged as a promising treatment for skin fibrosis. Here, we discuss the possible mechanism of skin fibrosis as well as the latest research about the mechanism of ASC therapy and its application in treating these conditions. ASC therapy provides a brand-new insight into the treatment of skin fibrosis.