Systematic Reviews
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2022; 14(8): 658-679
Published online Aug 26, 2022. doi: 10.4252/wjsc.v14.i8.658
How mesenchymal stem cell cotransplantation with hematopoietic stem cells can improve engraftment in animal models
Murilo Montenegro Garrigós, Fernando Anselmo de Oliveira, Mariana Penteado Nucci, Leopoldo Penteado Nucci, Arielly da Hora Alves, Olivia Furiama Metropolo Dias, Lionel Fernel Gamarra
Murilo Montenegro Garrigós, Fernando Anselmo de Oliveira, Mariana Penteado Nucci, Arielly da Hora Alves, Olivia Furiama Metropolo Dias, Lionel Fernel Gamarra, Hospital Israelita Albert Einstein, São Paulo 05652-900, São Paulo, Brazil
Murilo Montenegro Garrigós, Instituto de Química, Universidade de São Paulo, São Paulo 05508-900, São Paulo, Brazil
Mariana Penteado Nucci, LIM44-Hospital das Clínicas, Faculdade Medicina da Universidade de São Paulo, São Paulo 05403-000, Brazil
Leopoldo Penteado Nucci, Centro Universitário do Planalto Central, Área Especial para Industria nº 02 Setor Leste - Gama-DF, Brasília 72445-020, Distrito Federal, Brazil
Author contributions: Garrigós MM, de Oliveira FA and Gamarra LF, conceptualized and designed the review; de Oliveira FA, and Garrigós MM contributed to search of literature, data extraction and critical revision; Nucci MP, Nucci LP, Dias OFM, Alves AH and Gamarra LF carried out the analysis, drafted the manuscript and critical revision; all authors reviewed and approved the final manuscript as submitted.
Supported by CNPq, No. 308901/2020, No. 400856/2016-6; FAPESP, No. 2019/21070-3, No. 2017/17868-4, No. 2016/21470-3; SisNANO 2.0/MCTIC, No. 442539/2019-3; the National Institute of Science and Technology Complex Fluids (INCT-FCx); and “Amigos da Oncologia e Hematologia Einstein” AMIGOH.
Conflict-of-interest statement: The authors have declared that no competing interests exist.
PRISMA 2009 Checklist statement: The authors have read the PRISMA guideline and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lionel Fernel Gamarra, PhD, Academic Research, Full Professor, Research Scientist, Hospital Israelita Albert Einstein, Av Albert Einstein 640, São Paulo 05652-900, São Paulo, Brazil. lionelgamarra7@gmail.com
Received: March 15, 2022
Peer-review started: March 15, 2022
First decision: April 19, 2022
Revised: April 27, 2022
Accepted: July 26, 2022
Article in press: July 26, 2022
Published online: August 26, 2022
Processing time: 163 Days and 16.9 Hours
Core Tip

Core Tip: The systematic review provided a current view on the characteristics of mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) cotransplantation to achieve successful engraftment and improve hematopoietic reconstitution. The studies demonstrated a diversity in experimental designs and MSC isolation and characterization protocols; however, the lack of standardization in MSC use makes translation to clinical practice more difficult.