Review
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World J Stem Cells. Nov 26, 2022; 14(11): 777-797
Published online Nov 26, 2022. doi: 10.4252/wjsc.v14.i11.777
Profile of biological characterizations and clinical application of corneal stem/progenitor cells
Pei-Xi Ying, Min Fu, Chang Huang, Zhi-Hong Li, Qing-Yi Mao, Sheng Fu, Xu-Hui Jia, Yu-Chen Cao, Li-Bing Hong, Li-Yang Cai, Xi Guo, Ru-Bing Liu, Fan-ke Meng, Guo-Guo Yi
Pei-Xi Ying, Department of Ophthalmology, Zhujiang Hospital, The Second Clinical School, Southern Medical University, Guangzhou 510280, Guangdong Province, China
Min Fu, Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China
Chang Huang, Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200030, China
Chang Huang, NHC Key Laboratory of Myopia, Fudan University, Shanghai 200030, China
Chang Huang, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200030, China
Zhi-Hong Li, Department of Cardiology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Lab of Shock and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou 510550, Guangdong Province, China
Qing-Yi Mao, Xu-Hui Jia, Yu-Chen Cao, Li-Bing Hong, Li-Yang Cai, Ru-Bing Liu, The Second Clinical School, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Sheng Fu, Hengyang Medical School, The University of South China, Hengyang 421001, Hunan Province, China
Xi Guo, Medical College of Rehabilitation, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Fan-ke Meng, Emergency Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China
Guo-Guo Yi, Department of Ophthalmology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China
Author contributions: Ying PX, Mao QY, Huang C, Fu M, and Yi GG designed the research study; Jia XH, Cao YC, Hong LB, Cai LY, Guo X, Liu RB, Meng FK, Fu M, and Yi GG provided help and advice; Ying PX, Fu M, Mao QY, Huang C, Li ZH, and Fu S wrote the manuscript; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Guo Yi, MMed, Attending Doctor, Department of Ophthalmology, The Sixth Affiliated Hospital, Sun Yat-sen University, No. 26 Erheng Road, Yuancun, Guangzhou 510655, Guangdong Province, China. yigg@mail.sysu.edu.cn
Received: August 21, 2022
Peer-review started: August 21, 2022
First decision: October 31, 2022
Revised: November 8, 2022
Accepted: November 23, 2022
Article in press: November 23, 2022
Published online: November 26, 2022
Core Tip

Core Tip: The manuscript systematically reviewed three categories of stem cells or progenitor cells in cornea (including corneal epithelial stem cells, corneal endothelial cell progenitors and corneal stromal stem cells). There are two aspects of the manuscript that will make it interesting to general readers. Not only have we systematically introduced the anatomy, characteristics, cultivation and gene markers of these corneal stem cells, but also highlighted the bioengineering in the clinical application of these corneal stem cells. In addition, this manuscript is accompanied by beautiful figures and tables.