Basic Study
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World J Stem Cells. Jan 26, 2022; 14(1): 104-116
Published online Jan 26, 2022. doi: 10.4252/wjsc.v14.i1.104
Therapeutic effects of menstrual blood-derived endometrial stem cells on mouse models of streptozotocin-induced type 1 diabetes
Yu-Liang Sun, Ling-Rui Shang, Rui-Hong Liu, Xin-Yi Li, Sheng-Hui Zhang, Ya-Kun Ren, Kang Fu, Hong-Bin Cheng, Badrul Hisham Yahaya, Yan-Li Liu, Jun-Tang Lin
Yu-Liang Sun, Ling-Rui Shang, Xin-Yi Li, Yan-Li Liu, Jun-Tang Lin, Stem Cell and Biotherapy Technology Research Center, Xinxiang Medical University, Xinxiang 453000, Henan Province, China
Yu-Liang Sun, Badrul Hisham Yahaya, Regenerative Medicine Cluster, Advanced Medical and Dental Institute (IPPT), Universiti Sains Malaysia, Kepala Batas 13200, Penang, Malaysia
Rui-Hong Liu, Hong-Bin Cheng, Jun-Tang Lin, College of Biomedical Engineering, Xinxiang Medical University, Xinxiang 453000, Henan Province, China
Sheng-Hui Zhang, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang Medical University, Xinxiang 453000, Henan Province, China
Ya-Kun Ren, Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang 453000, Henan Province, China
Kang Fu, Department of Technical, Henan Intercell Biotechnology co. LTD, Xinxiang 453000, Henan Province, China
Author contributions: Sun YL and Shang LR contributed equally to this work; Cheng HB, Yahaya BH, Liu YL and Lin JT conceived the idea and designed the study; Sun YL, Liu RH, Li XY, Zhang SH, Ren YK, and Fu K contributed to the literature review and integrated the materials; Sun YL and Shang LR prepared the draft; Liu YL and Lin JT revised the manuscript and approved the final version as the corresponding authors; all the authors read and approved the final manuscript.
Supported by Henan Province Foundation of China, No. 202300410307 and No. 212102310611; Xinxiang City Foundation of China, No. GG2020009.
Institutional animal care and use committee statement: The research was reviewed and approved by Xinxiang Medical University.
Conflict-of-interest statement: The author declares that there is no conflict of interest at the time of publishing this article.
Data sharing statement: No additional data is available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jun-Tang Lin, PhD, Professor, Stem Cell and Biotherapy Technology Research Center, Xinxiang Medical University, East of JinSui Road, Xinxiang 453000, Henan Province, China.
Received: May 5, 2021
Peer-review started: May 5, 2021
First decision: June 23, 2021
Revised: July 20, 2021
Accepted: December 25, 2021
Article in press: December 25, 2021
Published online: January 26, 2022
Core Tip

Core Tip: Mesenchymal stem cell (MSC)-based therapies have resulted in promising improvements for patients with type 1 diabetes (T1D). Menstrual blood-derived endometrial stem cells (MenSC) transplantation has therapeutic effects equal to those of umbilical cord-derived MSC, which can significantly improve the symptoms of streptozotocin-induced T1D mice and exert protective effects on their main organs; MSC-induced angiogenesis, antiapoptotic effects and immunomodulation contribute to these protective effects. The results of this study showed that MenSC are expected to become a promising alternative for clinical diabetes treatment due to their advantages, including their regular and noninvasive collection protocol, abundant availability, and superior proliferative capacity.