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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2021; 13(4): 304-316
Published online Apr 26, 2021. doi: 10.4252/wjsc.v13.i4.304
Published online Apr 26, 2021. doi: 10.4252/wjsc.v13.i4.304
Orthobiologics in the treatment of hip disorders
André Vinícius Saueressig Kruel, Department of Orthopedics, Regenesis Clínica Médica, Bento Gonçalves, RS 95700-066, Brazil
Lucas Leite Ribeiro, Department of Orthopedics, Instituto Médico Salus, São Paulo, SP 01308-050, Brazil
Paulo David Gusmão, Department of Orthopedics, the Bone and Cartilage Institute, Porto Alegre, RS 90570-020, Brazil
Stephany Cares Huber, Department of Hematology, University of Campinas, Campinas, SP 13334-170, Brazil
José Fábio Santos Duarte Lana, Department of Orthopedics, the Bone and Cartilage Institute, Indaiatuba, SP 13334-170, Brazil
Author contributions: All authors contributed to the study conception and design. The body of the manuscript was written by Kruel A; Literature research was conducted by Ribeiro LL; Gusmão PD revised the draft and made suggestions for improvement; Huber SC formatted the manuscript and made all the necessary adjustments in order to prepare the manuscript for the submission process; Lana JFSD acted as the group leader, designing the main concepts and subtopics of discussion presented in the manuscript, critically revising both the initial and final versions of the manuscript before submission.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: André Vinícius Saueressig Kruel, MD, Chief Doctor, Surgeon, Department of Orthopedics, Regenesis Clínica Médica, Rua Doutor José Mário Mônaco, 333/302, Bento Gonçalves, RS 95700-066, Brazil. kruel.andre@gmail.com
Received: October 14, 2020
Peer-review started: October 14, 2020
First decision: December 12, 2020
Revised: December 26, 2020
Accepted: February 25, 2021
Article in press: February 25, 2021
Published online: April 26, 2021
Processing time: 189 Days and 18.2 Hours
Peer-review started: October 14, 2020
First decision: December 12, 2020
Revised: December 26, 2020
Accepted: February 25, 2021
Article in press: February 25, 2021
Published online: April 26, 2021
Processing time: 189 Days and 18.2 Hours
Core Tip
Core Tip: Orthobiologics are biological materials that are intended for the regeneration or healing of bone, cartilage and soft tissues. Commonly discussed orthobiologics include hyaluronic acid, platelet-rich plasma, bone marrow, adipose tissue and expanded mesenchymal stem cells. We explain the concepts and definitions of each orthobiologic and the literature regarding use for the hip joint. Each biological therapy has its own benefits and indications; however, it is important to note that the characterization of orthobiologics, injection method and evaluation analysis are of major importance for the use of biological therapies.