Kruel AVS, Ribeiro LL, Gusmão PD, Huber SC, Lana JFSD. Orthobiologics in the treatment of hip disorders. World J Stem Cells 2021; 13(4): 304-316 [PMID: 33959220 DOI: 10.4252/wjsc.v13.i4.304]
Corresponding Author of This Article
André Vinícius Saueressig Kruel, MD, Chief Doctor, Surgeon, Department of Orthopedics, Regenesis Clínica Médica, Rua Doutor José Mário Mônaco, 333/302, Bento Gonçalves, RS 95700-066, Brazil. kruel.andre@gmail.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Apr 26, 2021; 13(4): 304-316 Published online Apr 26, 2021. doi: 10.4252/wjsc.v13.i4.304
Orthobiologics in the treatment of hip disorders
André Vinícius Saueressig Kruel, Lucas Leite Ribeiro, Paulo David Gusmão, Stephany Cares Huber, José Fábio Santos Duarte Lana
André Vinícius Saueressig Kruel, Department of Orthopedics, Regenesis Clínica Médica, Bento Gonçalves, RS 95700-066, Brazil
Lucas Leite Ribeiro, Department of Orthopedics, Instituto Médico Salus, São Paulo, SP 01308-050, Brazil
Paulo David Gusmão, Department of Orthopedics, the Bone and Cartilage Institute, Porto Alegre, RS 90570-020, Brazil
Stephany Cares Huber, Department of Hematology, University of Campinas, Campinas, SP 13334-170, Brazil
José Fábio Santos Duarte Lana, Department of Orthopedics, the Bone and Cartilage Institute, Indaiatuba, SP 13334-170, Brazil
Author contributions: All authors contributed to the study conception and design. The body of the manuscript was written by Kruel A; Literature research was conducted by Ribeiro LL; Gusmão PD revised the draft and made suggestions for improvement; Huber SC formatted the manuscript and made all the necessary adjustments in order to prepare the manuscript for the submission process; Lana JFSD acted as the group leader, designing the main concepts and subtopics of discussion presented in the manuscript, critically revising both the initial and final versions of the manuscript before submission.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: André Vinícius Saueressig Kruel, MD, Chief Doctor, Surgeon, Department of Orthopedics, Regenesis Clínica Médica, Rua Doutor José Mário Mônaco, 333/302, Bento Gonçalves, RS 95700-066, Brazil. kruel.andre@gmail.com
Received: October 14, 2020 Peer-review started: October 14, 2020 First decision: December 12, 2020 Revised: December 26, 2020 Accepted: February 25, 2021 Article in press: February 25, 2021 Published online: April 26, 2021
Abstract
Orthobiologics are biological materials that are intended for the regeneration or healing of bone, cartilage and soft tissues. In this review we discuss the use of orthobiologics for hip disorders providing an update. The orthobiologics included in this article are hyaluronic acid, platelet rich plasma, bone marrow, adipose tissue and expanded mesenchymal stem cells. We explain the concepts and definitions of each orthobiological product, and the literature regarding its use in the hip joint. The paucity of guidelines for the production and characterization of the biological products leads to uneven results across the literature. Each biologic therapy has indications and benefits; however, noteworthy are the characterization of the orthobiologics, the application method and outcome analysis for further improvement of each technique.
Core Tip: Orthobiologics are biological materials that are intended for the regeneration or healing of bone, cartilage and soft tissues. Commonly discussed orthobiologics include hyaluronic acid, platelet-rich plasma, bone marrow, adipose tissue and expanded mesenchymal stem cells. We explain the concepts and definitions of each orthobiologic and the literature regarding use for the hip joint. Each biological therapy has its own benefits and indications; however, it is important to note that the characterization of orthobiologics, injection method and evaluation analysis are of major importance for the use of biological therapies.
