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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Oct 26, 2021; 13(10): 1480-1512
Published online Oct 26, 2021. doi: 10.4252/wjsc.v13.i10.1480
Considerations for the clinical use of stem cells in genitourinary regenerative medicine
Christophe Caneparo, Luis Sorroza-Martinez, Stéphane Chabaud, Julie Fradette, Stéphane Bolduc
Christophe Caneparo, Luis Sorroza-Martinez, Stéphane Chabaud, Julie Fradette, Stéphane Bolduc, Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Centre de Recherche du CHU de Québec-Université Laval, Axe Médecine Régénératrice, Quebec G1J1Z4, Canada
Julie Fradette, Stéphane Bolduc, Department of Surgery, Faculty of Medicine, Université Laval, Quebec G1V0A6, Canada
Author contributions: Caneparo C and Sorroza-Martinez L wrote the manuscript; both authors contributed equally; Chabaud S, Fradette J and Bolduc S, revised the manuscript; all the authors approved the submission.
Supported by the ‘Fonds de Recherche du Québec-Santé (FRQS) (C.C.); the Canadian Institutes of Health Research (to S.B. as PI and J.F. as co-PI), No. 258229; the Quebec Cell, Tissue and Gene Therapy Network-ThéCell (a thematic network supported by the FRQS).
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Stéphane Bolduc, FRCS, MD, Deputy Director, Professor, Surgeon, Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Centre de Recherche du CHU de Québec-Université Laval, Axe Médecine Régénératrice, CMDGT/ LOEX, Aile-R, CRCHU de Québec-Hôpital Enfant-Jésus, 1401, 18e Rue, Quebec G1J1Z4, Canada. stephane.bolduc@fmed.ulaval.ca
Received: April 30, 2021
Peer-review started: April 30, 2021
First decision: June 16, 2021
Revised: July 12, 2021
Accepted: September 14, 2021
Article in press: September 14, 2021
Published online: October 26, 2021
Processing time: 178 Days and 5.8 Hours
Core Tip

Core Tip: Considering the lack of adequate tissue to perform repair or replacement of organ/tissue for urologic patients, new strategies must be developed, and stem cell-based therapies and tissue engineering approaches seem promising therapeutic alternatives. A complete overview of stem cells used in urology will be presented with a focus on adipose-derived stem cells which have particularly drawn the attention of researchers. Finally, an innovative technique allowing tissue reconstruction without exogenous material, the self-assembly approach, will be presented.