Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jan 26, 2021; 13(1): 1-29
Published online Jan 26, 2021. doi: 10.4252/wjsc.v13.i1.1
Perspectives of pluripotent stem cells in livestock
Dharmendra Kumar, Thirumala R Talluri, Naresh L Selokar, Iqbal Hyder, Wilfried A Kues
Dharmendra Kumar, Naresh L Selokar, Animal Physiology and Reproduction Division, ICAR-Central Institute for Research on Buffaloes, Hisar 125001, India
Thirumala R Talluri, Equine Production Campus, ICAR-National Research Centre on Equines, Bikaner 334001, India
Iqbal Hyder, Department of Physiology, NTR College of Veterinary Science, Gannavaram 521102, India
Wilfried A Kues, Department of Biotechnology, Friedrich-Loeffler-Institute, Federal Institute of Animal Health, Neustadt 31535, Germany
Author contributions: Kumar D and Kues WA drafted and wrote the review; Talluri TR designed the figures; Hyder I and Selokar NL contributed to specific chapters; all authors read and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Dharmendra Kumar, PhD, Senior Scientist, Animal Physiology and Reproduction Division, ICAR-Central Institute for Research on Buffaloes, Hisar 125001, India.
Received: June 26, 2020
Peer-review started: June 26, 2020
First decision: September 18, 2020
Revised: September 28, 2020
Accepted: November 9, 2020
Article in press: November 9, 2020
Published online: January 26, 2021
Core Tip

Core Tip: The successful derivation of pluripotent stem cells (PSCs) from livestock represents an ideal model for the progress of veterinary, biomedical and regenerative medicine. The inherent properties of self-renewal and differentiation make PSCs an ideal raw biomaterial for innovative approaches in artificial reproductive techniques, cell-based therapy, disease modelling, drug testing, organ generation, breed conservation and in vitro meat production. In this review, we present the current status of PSCs application for the development of livestock farming and their potential applications for human welfare.