Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2020; 12(8): 761-775
Published online Aug 26, 2020. doi: 10.4252/wjsc.v12.i8.761
Human embryonic stem cells as an in vitro model for studying developmental origins of type 2 diabetes
Andy Chun-Hang Chen, Kai Fai Lee, William Shu Biu Yeung, Yin Lau Lee
Andy Chun-Hang Chen, Kai Fai Lee, Yin Lau Lee, Department of Obstetrics and Gynaecology, The University of Hong Kong, Hong Kong, China
Andy Chun-Hang Chen, Kai Fai Lee, William Shu Biu Yeung, Yin Lau Lee, Shenzhen Key Laboratory of Fertility Regulation, The University of Hong Kong Shenzhen Hospital, Shenzhen 518053, Guangdong Province, China
Author contributions: Chen ACH and Lee YL conceived the study and drafted the manuscript; Lee KF, Yeung WSB, and Lee YL contributed to critical revision and editing of the manuscript.
Supported by a small project grant from the University of Hong Kong, No. 201409176196.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yin Lau Lee, PhD, Research Scientist, Department of Obstetrics and Gynaecology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China. cherielee@hku.hk
Received: March 12, 2020
Peer-review started: March 12, 2020
First decision: April 25, 2020
Revised: April 28, 2020
Accepted: June 14, 2020
Article in press: June 14, 2020
Published online: August 26, 2020
Processing time: 166 Days and 16.3 Hours
Core Tip

Core tip: The study of the mechanisms by which the intrauterine environment regulates offspring health is important. In this review, we will discuss the use of human embryonic stem cells as an in vitro model for understanding the developmental origins of diseases such as type 2 diabetes.