Souza GT, Maranduba CP, Souza CM, Amaral DLASD, Guia FCD, Zanette RSS, Rettore JVP, Rabelo NC, Nascimento LM, Pinto &FN, Farani JB, Neto AEH, Silva FS, Maranduba CMDC, Atalla A. Advances in cellular technology in the hematology field: What have we learned so far? World J Stem Cells 2015; 7(1): 106-115 [PMID: 25621110 DOI: 10.4252/wjsc.v7.i1.106]
Corresponding Author of This Article
Angelo Atalla, PhD, Haematology and Bone Marrow Transplantation Service, Medical Clinic Department, University Hospital, Federal University of Juiz de Fora, R José Lourenço Kelmer-Martelos, Juiz de Fora 36036-900, Brazil. angeloatalla@yahoo.com
Research Domain of This Article
Cell Biology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Jan 26, 2015; 7(1): 106-115 Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.106
Advances in cellular technology in the hematology field: What have we learned so far?
Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Lucas Mendes Nascimento, Ícaro França Navarro Pinto, Júlia Boechat Farani, Abrahão Elias Hallack Neto, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Angelo Atalla
Gustavo Torres de Souza, Claudinéia Pereira Maranduba, Camila Maurmann de Souza, Danielle Luciana Aurora Soares do Amaral, Francisco Carlos da Guia, Rafaella de Souza Salomão Zanette, João Vitor Paes Rettore, Natana Chaves Rabelo, Fernando de Sá Silva, Carlos Magno da Costa Maranduba, Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil
Lucas Mendes Nascimento, Ícaro França Navarro Pinto, Júlia Boechat Farani, Abrahão Elias Hallack Neto, Angelo Atalla, Haematology and Bone Marrow Transplantation Service, Medical Clinic Department, University Hospital, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil
Author contributions: All the authors contributed to this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Angelo Atalla, PhD, Haematology and Bone Marrow Transplantation Service, Medical Clinic Department, University Hospital, Federal University of Juiz de Fora, R José Lourenço Kelmer-Martelos, Juiz de Fora 36036-900, Brazil. angeloatalla@yahoo.com
Telephone: +55-32-40095100
Received: July 25, 2014 Peer-review started: July 26, 2014 First decision: August 28, 2014 Revised: September 14, 2014 Accepted: September 18, 2014 Article in press: December 16, 2014 Published online: January 26, 2015 Processing time: 172 Days and 13.7 Hours
Abstract
Despite the advances in the hematology field, blood transfusion-related iatrogenesis is still a major issue to be considered during such procedures due to blood antigenic incompatibility. This places pluripotent stem cells as a possible ally in the production of more suitable blood products. The present review article aims to provide a comprehensive summary of the state-of-the-art concerning the differentiation of both embryonic stem cells and induced pluripotent stem cells to hematopoietic cell lines. Here, we review the most recently published protocols to achieve the production of blood cells for future application in hemotherapy, cancer therapy and basic research.
Core tip: In the past few years, considerable advance has been made possible in the field of cellular therapy, both in its basic and clinically applied form. Stem cells may have important future applications in hematology, with the possibility of supplying the blood needed for transfusion with the use of blood products produced in vitro. Thus, in this paper, we summarize the recently established protocols for differentiating both embryonic and induced pluripotent stem cells into blood cells for possible future use for hemotherapy.
