Shi L, Lu PP, Dai GC, Li YJ, Rui YF. Advanced glycation end productions and tendon stem/progenitor cells in pathogenesis of diabetic tendinopathy. World J Stem Cells 2021; 13(9): 1338-1348 [PMID: 34630866 DOI: 10.4252/wjsc.v13.i9.1338]
Corresponding Author of This Article
Yun-Feng Rui, MD, PhD, Deputy Director, Professor, Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Ding Jia Qiao, Nanjing 210009, Jiangsu Province, China. ruiyunfeng@126.com
Research Domain of This Article
Sport Sciences
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Sep 26, 2021; 13(9): 1338-1348 Published online Sep 26, 2021. doi: 10.4252/wjsc.v13.i9.1338
Advanced glycation end productions and tendon stem/progenitor cells in pathogenesis of diabetic tendinopathy
Liu Shi, Pan-Pan Lu, Guang-Chun Dai, Ying-Juan Li, Yun-Feng Rui
Liu Shi, Pan-Pan Lu, Guang-Chun Dai, Yun-Feng Rui, Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Ying-Juan Li, Department of Geriatrics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Author contributions: Shi L wrote the paper; Lu PP provided assistance with the figure preparation; Dai GC assisted in performing the search and collection of the relevant publications; Li YJ provided input during the drafting of the paper; Rui YF revised and proofread the paper.
Supported byNational Natural Science Foundation of China, No. 81572187 and No. 81871812; Jiangsu Provincial Medical Talent, The Project of Invigorating Health Care through Science, Technology and Education, No. ZDRCA2016083; Natural Science Foundation of Jiangsu Province for Young Scholars, China, No. BK20200398; Entrepreneurship and Innovation Program of Jiangsu Province, China, No. 1190000054; and The Six Projects Sponsoring Talent Summits of Jiangsu Province, China, No. LGY2017099.
Conflict-of-interest statement: The authors have no conflict of interest for this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Feng Rui, MD, PhD, Deputy Director, Professor, Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, No. 87 Ding Jia Qiao, Nanjing 210009, Jiangsu Province, China. ruiyunfeng@126.com
Received: April 6, 2021 Peer-review started: April 6, 2021 First decision: May 12, 2021 Revised: May 26, 2021 Accepted: August 17, 2021 Article in press: August 17, 2021 Published online: September 26, 2021 Processing time: 165 Days and 9 Hours
Abstract
Tendinopathy is a challenging complication observed in patients with diabetes mellitus. Tendinopathy usually leads to chronic pain, limited joint motion, and even ruptured tendons. Imaging and histological analyses have revealed pathological changes in various tendons of patients with diabetes, including disorganized arrangement of collagen fibers, microtears, calcium nodules, and advanced glycation end product (AGE) deposition. Tendon-derived stem/ progenitor cells (TSPCs) were found to maintain hemostasis and to participate in the reversal of tendinopathy. We also discovered the aberrant osteochondrogenesis of TSPCs in vitro. However, the relationship between AGEs and TSPCs in diabetic tendinopathy and the underlying mechanism remain unclear. In this review, we summarize the current findings in this field and hypothesize that AGEs could alter the properties of tendons in patients with diabetes by regulating the proliferation and differentiation of TSPCs in vivo.
Core Tip: Patients with diabetic tendinopathy usually suffer from chronic pain, restricted joint motion, calcium deposition, and even tendon rupture. Advanced glycation end products (AGEs) have been shown to affect tendon biology and biomechanical properties. In addition, tendon-derived stem/progenitor cells (TSPCs) play an important role in tendon hemostasis, regeneration, and repair. However, the relationships between diabetic tendinopathy, AGEs, and TSPCs remain unclear. Thus, in this review, we summarize the current findings and discuss the possible relationships between AGEs and TSPCs. This might provide new guidance for the development of effective treatments for diabetic tendinopathy.
