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For: García-Sánchez D, Fernández D, Rodríguez-Rey JC, Pérez-Campo FM. Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells. World J Stem Cells 2019; 11(10): 748-763 [PMID: 31692976 DOI: 10.4252/wjsc.v11.i10.748]
URL: https://www.wjgnet.com/1948-0210/full/v11/i10/748.htm
Number Citing Articles
1
Cheng Huang, Zeqin Wen, Junjie Niu, Subin Lin, Weiguo Wang. Steroid-Induced Osteonecrosis of the Femoral Head: Novel Insight Into the Roles of Bone Endothelial Cells in Pathogenesis and TreatmentFrontiers in Cell and Developmental Biology 2021; 9 doi: 10.3389/fcell.2021.777697
2
Rosa M. Pasculli, Charles D. Kenyon, William A. Berrigan, Kenneth Mautner, Kyle Hammond, Prathap Jayaram. Mesenchymal stem cells for subchondral bone marrow lesions: From bench to bedsideBone Reports 2022; 17: 101630 doi: 10.1016/j.bonr.2022.101630
3
Nadia Lampiasi. The Migration and the Fate of Dental Pulp Stem CellsBiology 2023; 12(5): 742 doi: 10.3390/biology12050742
4
Alberto González-González, Daniel García-Sánchez, Monica Dotta, José C Rodríguez-Rey, Flor M Pérez-Campo. Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicineWorld Journal of Stem Cells 2020; 12(12): 1529-1552 doi: 10.4252/wjsc.v12.i12.1529
5
Mingyao Wang, Xinxuan Xu, Xiongxin Lei, Jie Tan, Huiqi Xie. Mesenchymal stem cell-based therapy for burn wound healingBurns & Trauma 2021; 9 doi: 10.1093/burnst/tkab002
6
Chih-Wei Zeng. Advancing Spinal Cord Injury Treatment through Stem Cell Therapy: A Comprehensive Review of Cell Types, Challenges, and Emerging Technologies in Regenerative MedicineInternational Journal of Molecular Sciences 2023; 24(18): 14349 doi: 10.3390/ijms241814349
7
Qu Yang, Qi Chen, Sihui Li, Jun Luo. Mesenchymal stem cells ameliorate inflammation and pyroptosis in diabetic cardiomyopathy via the miRNA-223-3p/NLRP3 pathwayDiabetology & Metabolic Syndrome 2024; 16(1) doi: 10.1186/s13098-024-01389-7
8
Deogil Kim, Hyejong Choi, Min-Ju Lee, Woong Jin Cho, Gun Woo Lee, Young-Kwon Seo, Yoshie Arai, Soo-Hong Lee. Oxygen plasma-modified polycaprolactone nanofiber membrane activates the biological function in cell adhesion, proliferation, and migration through the phosphorylation of FAK and ERK1/2, enhancing bone regenerationChemical Engineering Journal 2024; 499: 156003 doi: 10.1016/j.cej.2024.156003
9
Jiayu Chen, Zhanliang Liu, Huicheng Zhang, Yongqian Yang, Huangxiang Zeng, Rongwei Zhong, Shangdao Lai, Hongxing Liao. YBX1 Promotes MSC Osteogenic Differentiation by Activating the PI3K/AKT PathwayCurrent Stem Cell Research & Therapy 2023; 18(4): 513 doi: 10.2174/1574888X17666220805143833
10
Zhengqi Hu, Zhiliang Jiang, Shengzi Meng, Rong Liu, Kun Yang. Research Progress on the Osteogenesis-Related Regulatory Mechanisms of Human Umbilical Cord Mesenchymal Stem CellsStem Cell Reviews and Reports 2023; 19(5): 1252 doi: 10.1007/s12015-023-10521-5
11
Min Yin, Yan Zhang, Haibo Yu, Xia Li. Role of Hyperglycemia in the Senescence of Mesenchymal Stem CellsFrontiers in Cell and Developmental Biology 2021; 9 doi: 10.3389/fcell.2021.665412
12
Hee Won Park, Chae Eun Lee, Sungjun Kim, Woo-Jin Jeong, Kyobum Kim. Ex Vivo Peptide Decoration Strategies on Stem Cell Surfaces for Augmenting Endothelium InteractionTissue Engineering Part B: Reviews 2024; 30(3): 327 doi: 10.1089/ten.teb.2023.0210
13
Annalisa Bruno, Cristina Milillo, Federico Anaclerio, Carlotta Buccolini, Anastasia Dell’Elice, Ilaria Angilletta, Marco Gatta, Patrizia Ballerini, Ivana Antonucci. Perinatal Tissue-Derived Stem Cells: An Emerging Therapeutic Strategy for Challenging Neurodegenerative DiseasesInternational Journal of Molecular Sciences 2024; 25(2): 976 doi: 10.3390/ijms25020976
14
Yang Sun, Qianrong Zhou, Yawei Du, Jian Sun, Wei Bi, Wenjuan Liu, Ruixue Li, Xingwen Wu, Fei Yang, Liang Song, Ni Li, Wenguo Cui, Youcheng Yu. Dual Biosignal‐Functional Injectable Microspheres for Remodeling Osteogenic MicroenvironmentSmall 2022; 18(36) doi: 10.1002/smll.202201656
15
Ramyar Rahimi Darehbagh, Seyedeh Asrin Seyedoshohadaei, Rojin Ramezani, Nima Rezaei. Stem cell therapies for neurological disorders: current progress, challenges, and future perspectivesEuropean Journal of Medical Research 2024; 29(1) doi: 10.1186/s40001-024-01987-1
16
Johnny Kuan Un Wong, Ashish Mehta, Thu Thủy Vũ, Giselle C. Yeo. Cellular modifications and biomaterial design to improve mesenchymal stem cell transplantationBiomaterials Science 2023; 11(14): 4752 doi: 10.1039/D3BM00376K
17
Negin Afsharzadeh, Fahimeh Lavi Arab, Mojtaba Sankian, Leila Samiei, Nafiseh Sadat Tabasi, Danial Afsharzadeh, Karim Nikkhah, Mahmoud Mahmoudi. Comparative assessment of proliferation and immunomodulatory potential of Hypericum perforatum plant and callus extracts on mesenchymal stem cells derived adipose tissue from multiple sclerosis patientsInflammopharmacology 2021; 29(5): 1399 doi: 10.1007/s10787-021-00838-3
18
Armin Khosravipour, Abdollah Amini, Reza Masteri Farahani, Atarodalsadat Mostafavinia, Mehrdad Asgari, Fatemehalsadat Rezaei, Heidi Abrahamse, Sufan Chien, Mohammad Bayat. Evaluation of the effects of preconditioned human stem cells plus a scaffold and photobiomodulation administration on stereological parameters and gene expression levels in a critical size bone defect in ratsLasers in Medical Science 2022; 37(5): 2457 doi: 10.1007/s10103-022-03509-z
19
Jun Zhang, Ziming Liu, Yuwan Li, Qi You, Jibin Yang, Ying Jin, Gang Zou, Jingfeng Tang, Zhen Ge, Yi Liu. FGF-2-Induced Human Amniotic Mesenchymal Stem Cells Seeded on a Human Acellular Amniotic Membrane Scaffold Accelerated Tendon-to-Bone Healing in a Rabbit Extra-Articular ModelStem Cells International 2020; 2020: 1 doi: 10.1155/2020/4701476
20
Seyed Danial Alizadeh, Shima Jahani, Mohammad Rezaei Zadeh Rukerd, Reza Tabrizi, Rasoul Masoomi, Seyedeh Zahra Banihashemian, Mahgol Sadat Hassan Zadeh Tabatabaei, Zahra Ghodsi, Ahmad Pour-Rashidi, James Harrop, Vafa Rahimi-Movaghar. Human studies of the efficacy and safety of stem cells in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysisStem Cell Research & Therapy 2024; 15(1) doi: 10.1186/s13287-024-04033-3
21
Surakshya Shrestha, Fanyi Li, Vinh X. Truong, John S. Forsythe, Jessica E. Frith. Interplay of Hydrogel Composition and Geometry on Human Mesenchymal Stem Cell OsteogenesisBiomacromolecules 2020; 21(12): 5323 doi: 10.1021/acs.biomac.0c01408
22
Xiao Xu, Limei Xu, Jiang Xia, Caining Wen, Yujie Liang, Yuanmin Zhang. Harnessing knee joint resident mesenchymal stem cells in cartilage tissue engineeringActa Biomaterialia 2023; 168: 372 doi: 10.1016/j.actbio.2023.07.024
23
Nazmul Haque, Noor Hayaty Abu Kasim, Pratiwi Soesilawati, Elly Munadziroh. iPSC Derived Progenitors2022; : 177 doi: 10.1016/B978-0-323-85545-7.00011-9
24
Qiting He, Hengshuo Zhang, Beibei Hu, Xuezhou Li, Yunpeng Wu, Pengfei Sun, Yuhua Jia, Lei Cheng, Yongyuan Guo. CircRNA hsa_circ_0001421 promotes the osteoblast differentiation of human adipose mesenchymal stem cells through the miR-608/SP7 axisBiochemical Engineering Journal 2022; 181: 108386 doi: 10.1016/j.bej.2022.108386
25
E.A.F. Bordini, F.B. Cassiano, E.S. Bronze-Uhle, L. Alamo, J. Hebling, C.A. de Souza Costa, D.G. Soares. Chitosan in association with osteogenic factors as a cell-homing platform for dentin regeneration: Analysis in a pulp-in-a-chip modelDental Materials 2022; 38(4): 655 doi: 10.1016/j.dental.2022.02.004
26
Heng Zhou, Yan He, Wei Xiong, Shuili Jing, Xingxiang Duan, Zhiyun Huang, Gurek S. Nahal, Youjian Peng, Mingchang Li, Yaoqi Zhu, Qingsong Ye. MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseasesBioactive Materials 2023; 23: 409 doi: 10.1016/j.bioactmat.2022.11.007
27
M.D. Tronko, V.M. Pushkarev, O.I. Kovzun, L.K. Sokolova, V.V. Pushkarev. Мезенхімальні стовбурові клітини — головний ресурс клітинної терапії. Використання для лікування цукрового діабетуEndokrynologia 2022; 27(3): 214 doi: 10.31793/1680-1466.2022.27-3.214
28
Mehdi Najar, Johanne Martel-Pelletier, Jean Pierre Pelletier, Hassan Fahmi. Novel insights for improving the therapeutic safety and efficiency of mesenchymal stromal cellsWorld Journal of Stem Cells 2020; 12(12): 1474-1491 doi: 10.4252/wjsc.v12.i12.1474
29
Arturo Ibáñez-Fonseca, Ana Rico, Silvia Preciado, Fernando González-Pérez, Sandra Muntión, Jesús García-Briñón, María-Carmen García-Macías, José Carlos Rodríguez-Cabello, Miguel Pericacho, Matilde Alonso, Fermín Sánchez-Guijo. Mesenchymal Stromal Cells Combined With Elastin-Like Recombinamers Increase Angiogenesis In Vivo After Hindlimb IschemiaFrontiers in Bioengineering and Biotechnology 2022; 10 doi: 10.3389/fbioe.2022.918602
30
Youde Liang, Ruiping Zhou, Xin Liu, Lin You, Chang Chen, Xiaoling Ye, Wei Wei, Jie Liu, Jiawei Dai, Kaixiong Li, Xiangxiang Zhao, Tian Li. Leukemia Inhibitory Factor Facilitates Self-Renewal and Differentiation and Attenuates Oxidative Stress of BMSCs by Activating PI3K/AKT SignalingOxidative Medicine and Cellular Longevity 2022; 2022: 1 doi: 10.1155/2022/5772509
31
Dickson Kofi Wiredu Ocansey, Bing Pei, Yongmin Yan, Hui Qian, Xu Zhang, Wenrong Xu, Fei Mao. Improved therapeutics of modified mesenchymal stem cells: an updateJournal of Translational Medicine 2020; 18(1) doi: 10.1186/s12967-020-02234-x
32
Calvin Chang, Jerry Yan, Zhicheng Yao, Chi Zhang, Xiaowei Li, Hai‐Quan Mao. Effects of Mesenchymal Stem Cell‐Derived Paracrine Signals and Their Delivery StrategiesAdvanced Healthcare Materials 2021; 10(7) doi: 10.1002/adhm.202001689
33
Fang Wang, Zheng Jing, Ting Wei, Hui Jiang, Xiaojun Li, Bo Li. Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem CellsEvidence-Based Complementary and Alternative Medicine 2022; 2022: 1 doi: 10.1155/2022/1630260
34
Nur Yasmin Diana Binti Lokman Hakim, Steven Noble, Natasya Valentina Thomas, Binushi Sandunika Geegana Gamage, Ganeson-Koo Maxwell, Vijayendran Govindasamy, Kong-Yong Then, Anjan Kumar Das, Soon-Keng Cheong. Genetic Modification as a New Approach to Ameliorate the Therapeutic Efficacy of Stem Cells in Diabetic RetinopathyEuropean Journal of Ophthalmology 2022; 32(2): 741 doi: 10.1177/11206721211073430
35
Venkata Suresh Venkataiah, Yoshio Yahata, Akira Kitagawa, Masahiko Inagaki, Yusuke Kakiuchi, Masato Nakano, Shigeto Suzuki, Keisuke Handa, Masahiro Saito. Clinical Applications of Cell-Scaffold Constructs for Bone Regeneration TherapyCells 2021; 10(10): 2687 doi: 10.3390/cells10102687
36
Kangkang Zha, Yue Tian, Adriana C. Panayi, Bobin Mi, Guohui Liu. Recent Advances in Enhancement Strategies for Osteogenic Differentiation of Mesenchymal Stem Cells in Bone Tissue EngineeringFrontiers in Cell and Developmental Biology 2022; 10 doi: 10.3389/fcell.2022.824812
37
Giulia Carozza, Darin Zerti, Fanny Pulcini, Loreto Lancia, Simona Delle Monache, Vincenzo Mattei, Rita Maccarone. Conditioned media from dental pulp stem cells to counteract age-related macular degenerationExperimental Eye Research 2025; 250: 110167 doi: 10.1016/j.exer.2024.110167
38
Simona Delle Monache, Fanny Pulcini, Francesca Santilli, Stefano Martellucci, Costantino Santacroce, Jessica Fabrizi, Adriano Angelucci, Maurizio Sorice, Vincenzo Mattei. Hypoxia Induces DPSC Differentiation versus a Neurogenic Phenotype by the Paracrine MechanismBiomedicines 2022; 10(5): 1056 doi: 10.3390/biomedicines10051056
39
Fen Liu, Tianyu Sun, Ying An, Leiguo Ming, Yinghui Li, Zhifei Zhou, Fengqing Shang. The potential therapeutic role of extracellular vesicles in critical-size bone defects: Spring of cell-free regenerative medicine is comingFrontiers in Bioengineering and Biotechnology 2023; 11 doi: 10.3389/fbioe.2023.1050916
40
Stephanie L. Tsai, Marie‐Therese Nödl, Jenna L. Galloway. Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategiesDevelopmental Dynamics 2021; 250(3): 393 doi: 10.1002/dvdy.269
41
Joaquín Villarreal Barragán, Mira Mousa, Nupur Kohli. From Cord to Cure: Repurposing Biological Waste for UAE's Health Revolution with Umbilical Cord Stem Cell TherapyGulf Education and Social Policy Review (GESPR) 2024;  doi: 10.18502/gespr.v5i2.16916
42
Farid Amansyah, B. Budu, Muhammad Harun Achmad, Nu’man A.S. Daud, Agung Putra, Muhammad Nasrum Massi, Agussalim Bukhari, Marhaen Hardjo, Luthfi Parewangi, Ilhamjaya Patellongi. Secretome of Hypoxia-Preconditioned Mesenchymal Stem Cells Promotes Liver Regeneration and Anti-Fibrotic Effect in Liver Fibrosis Animal ModelPakistan Journal of Biological Sciences 2024; 27(1): 18 doi: 10.3923/pjbs.2024.18.26
43
Tito Sumarwoto, Heri Suroto, Dwikora Novembri Utomo, Cita Rosita Sigit Prakoeswa, Damayanti Tinduh, Hari Basuki Notobroto, Nur Arfian, Fedik Abdul Rantam, Sholahuddin Rhatomy, Ferdiansyah Mahyudin. The effect of preconditioning hypoxia in schwann-like-cells-derived adipose mesenchymal stem cells and rat sciatic nerve-derived stem cells: experimental researchAnnals of Medicine & Surgery 2023; 85(7): 3439 doi: 10.1097/MS9.0000000000000777
44
Meadhbh Á. Brennan, David S. Monahan, Bénédicte Brulin, Sara Gallinetti, Paul Humbert, Christina Tringides, Cristina Canal, Maria Pau Ginebra, Pierre Layrolle. Biomimetic versus sintered macroporous calcium phosphate scaffolds enhanced bone regeneration and human mesenchymal stromal cell engraftment in calvarial defectsActa Biomaterialia 2021; 135: 689 doi: 10.1016/j.actbio.2021.09.007
45
Logeshwaran Somasundaram, Shiri Levy, Abdiasis M. Hussein, Devon D. Ehnes, Julie Mathieu, Hannele Ruohola-Baker. Stem Cell Proliferation and DifferentiationCurrent Topics in Developmental Biology 2020; 138: 209 doi: 10.1016/bs.ctdb.2020.02.003
46
Jan Barekzai, Florian Petry, Peter Czermak, Denise Salzig. Cell Culture Engineering and TechnologyCell Engineering 2021; 10: 307 doi: 10.1007/978-3-030-79871-0_10
47
Lars Tasto, Denise Salzig. Biopharmaceutical ManufacturingCell Engineering 2023; 11: 379 doi: 10.1007/978-3-031-45669-5_13
48
Jinli Zhang, Zhihe Liu, Yang Luo, Xiaojian Li, Guowei Huang, Huan Chen, Aiguo Li, Shengnan Qin. The Role of Flavonoids in the Osteogenic Differentiation of Mesenchymal Stem CellsFrontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.849513
49
Haixia Xu, Chengqiang Wang, Chun Liu, Ziyue Peng, Jianjun Li, Yanglei Jin, Yihan Wang, Jiasong Guo, Lixin Zhu. Cotransplantation of mesenchymal stem cells and endothelial progenitor cells for treating steroid-induced osteonecrosis of the femoral headStem Cells Translational Medicine 2021; 10(5): 781 doi: 10.1002/sctm.20-0346
50
Agata Nowak-Stępniowska, Paulina Natalia Osuchowska, Henryk Fiedorowicz, Elżbieta Anna Trafny, Yibo Gan. Insight in Hypoxia-Mimetic Agents as Potential Tools for Mesenchymal Stem Cell Priming in Regenerative MedicineStem Cells International 2022; 2022: 1 doi: 10.1155/2022/8775591
51
N. V. Pak, E. V. Murzina, N. V. Aksenova, T. G. Krylova, V. N. Aleksandrov. Effect of the delivery route and dose of multipotent mesenchymal stem cells on the efficacy of cell therapy (review)Russian Journal of Transplantology and Artificial Organs 2024; 26(2): 126 doi: 10.15825/1995-1191-2024-2-126-134
52
Liping Tan, Xuan Liu, Huan Dou, Yayi Hou. Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment — specific factors involved in the regulation of MSC plasticityGenes & Diseases 2022; 9(2): 296 doi: 10.1016/j.gendis.2020.10.006
53
Simon Kwoon-Ho Chow, Qi Gao, Alexa Pius, Mayu Morita, Yasemin Ergul, Masatoshi Murayama, Issei Shinohara, Mehmet Sertac Cekuc, Chao Ma, Yosuke Susuki, Stuart B. Goodman. The Advantages and Shortcomings of Stem Cell Therapy for Enhanced Bone HealingTissue Engineering Part C: Methods 2024; 30(10): 415 doi: 10.1089/ten.tec.2024.0252
54
Sandra Hinkelmann, Alexandra H. Springwald, Annett Starke, Hermann Kalwa, Christian Wölk, Michael C. Hacker, Michaela Schulz-Siegmund. Microtissues from mesenchymal stem cells and siRNA-loaded cross-linked gelatin microparticles for bone regenerationMaterials Today Bio 2022; 13: 100190 doi: 10.1016/j.mtbio.2021.100190
55
Gunticha Suwanmanee, Chairat Tantrawatpan, Pakpoom Kheolamai, Luminita Paraoan, Sirikul Manochantr. Fucoxanthin diminishes oxidative stress damage in human placenta-derived mesenchymal stem cells through the PI3K/Akt/Nrf-2 pathwayScientific Reports 2023; 13(1) doi: 10.1038/s41598-023-49751-5
56
Natalia Yudintceva, Natalia Mikhailova, Viacheslav Fedorov, Konstantin Samochernych, Tatiana Vinogradova, Alexandr Muraviov, Maxim Shevtsov. Mesenchymal Stem Cells and MSCs-Derived Extracellular Vesicles in Infectious Diseases: From Basic Research to Clinical PracticeBioengineering 2022; 9(11): 662 doi: 10.3390/bioengineering9110662
57
Yamuna Mohanram, Jingying Zhang, Eleftherios Tsiridis, Xuebin B. Yang. Comparing bone tissue engineering efficacy of HDPSCs, HBMSCs on 3D biomimetic ABM-P-15 scaffolds in vitro and in vivoCytotechnology 2020; 72(5): 715 doi: 10.1007/s10616-020-00414-7
58
Paloma Fuentes, María José Torres, Rodrigo Arancibia, Francisco Aulestia, Mauricio Vergara, Flavio Carrión, Nelson Osses, Claudia Altamirano. Dynamic Culture of Mesenchymal Stromal/Stem Cell Spheroids and Secretion of Paracrine FactorsFrontiers in Bioengineering and Biotechnology 2022; 10 doi: 10.3389/fbioe.2022.916229
59
Hanbing Liang, Qian Li, Ning Wang, Chunxiong Wang, Shaojing Shi, Haoqing Yang, Yangyang Cao, Ruitang Shi, Luyuan Jin, Chen Zhang. KDM4D enhances osteo/dentinogenic differentiation and migration of SCAPs via binding to RPS5Oral Diseases 2023; 29(7): 2827 doi: 10.1111/odi.14479
60
Stuart B. Goodman, Tzuhua Lin. Modifying MSC Phenotype to Facilitate Bone Healing: Biological ApproachesFrontiers in Bioengineering and Biotechnology 2020; 8 doi: 10.3389/fbioe.2020.00641
61
Francesca Posa, Adriana Di Benedetto, Giampietro Ravagnan, Elisabetta Ada Cavalcanti-Adam, Lorenzo Lo Muzio, Gianluca Percoco, Giorgio Mori. Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of OligostilbenesMaterials 2020; 13(20): 4471 doi: 10.3390/ma13204471
62
Arantza Infante, Natividad Alcorta-Sevillano, Iratxe Macías, Clara I. Rodríguez. Educating EVs to Improve Bone Regeneration: Getting Closer to the ClinicInternational Journal of Molecular Sciences 2022; 23(3): 1865 doi: 10.3390/ijms23031865
63
Songzi Zhang, Yunhwan Lee, Yanting Liu, Yerin Yu, Inbo Han. Stem Cell and Regenerative Therapies for the Treatment of Osteoporotic Vertebral Compression FracturesInternational Journal of Molecular Sciences 2024; 25(9): 4979 doi: 10.3390/ijms25094979
64
Yuichi Morita, Naoaki Sakata, Masuhiro Nishimura, Ryo Kawakami, Masayuki Shimizu, Gumpei Yoshimatsu, Osamu Sawamoto, Shinichi Matsumoto, Hideichi Wada, Shohta Kodama. Efficacy of Neonatal Porcine Bone Marrow–Derived Mesenchymal Stem Cell Xenotransplantation for the Therapy of Hind Limb Lymphedema in MiceCell Transplantation 2024; 33 doi: 10.1177/09636897241260195
65
Genu TAKAHASHI, Kyota YOSHINO, Yuki MORI, Takeru FUKAZAWA, Masaya WATADA, Akira MORI. Effects of Atmospheric Low Temperature Pressure Plasma on Bone Fracture MechanismsJournal of the Japan Society of Applied Electromagnetics and Mechanics 2023; 31(2): 319 doi: 10.14243/jsaem.31.319