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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2020; 12(12): 1529-1552
Published online Dec 26, 2020. doi: 10.4252/wjsc.v12.i12.1529
Published online Dec 26, 2020. doi: 10.4252/wjsc.v12.i12.1529
Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine
Alberto González-González, Daniel García-Sánchez, Monica Dotta, José C Rodríguez-Rey, Flor M Pérez-Campo, Department of Molecular Biology_IDIVAL, Faculty of Medicine, University of Cantabria, Santander 39011, Cantabria, Spain
Author contributions: González-González A, García-Sánchez D, Dotta M, Rodríguez-Rey JC, and Pérez-Campo FM wrote and approved the final version of the manuscript.
Supported by Spanish Ministerio de Economía y Competitividad , No. RTI2018-097324 ; Pre-doctoral program in Biomedicine from the University of Cantabria and the Instituto de Investigación Valdecilla (IDIVAL) , No. PREVAL 19/02 and PREVAL 20/01 .
Conflict-of-interest statement: None of the authors have any conflicts of interest relevant to this study.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Flor M Pérez-Campo, BSc, MSc, PhD, Assistant Professor, Senior Scientist, Department of Molecular Biology_IDIVAL, Faculty of Medicine, University of Cantabria, Avda Cardenal Herrera Oria S/N, Santander 39011, Cantabria, Spain. f.perezcampo@unican.es
Received: June 29, 2020
Peer-review started: June 29, 2020
First decision: September 24, 2020
Revised: October 7, 2020
Accepted: November 11, 2020
Article in press: November 11, 2020
Published online: December 26, 2020
Processing time: 180 Days and 8 Hours
Peer-review started: June 29, 2020
First decision: September 24, 2020
Revised: October 7, 2020
Accepted: November 11, 2020
Article in press: November 11, 2020
Published online: December 26, 2020
Processing time: 180 Days and 8 Hours
Core Tip
Core Tip: Mesenchymal stem cells (MSCs) produce a high number of bioactive molecules and extracellular vesicles, known as secretome, which exerts important paracrine effects on neighbouring cells and tissues. The use of MSCs secretome in tissue regeneration therapies would circumvent the problems linked to MSCs-based therapies, such as low cell survival and engraftment, which importantly limit their therapeutic efficacy, or the negative side effects associated with the administration of these cells.