Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2022; 28(25): 2900-2909
Published online Jul 7, 2022. doi: 10.3748/wjg.v28.i25.2900
Published online Jul 7, 2022. doi: 10.3748/wjg.v28.i25.2900
Role of transcribed ultraconserved regions in gastric cancer and therapeutic perspectives
Shen-Shuo Gao, Zhi-Kai Zhang, Yan Ma, Xiao-Bo Guo, Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250021, Shandong Province, China
Xu-Bin Wang, Yan Ma, Xiao-Bo Guo, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Guo-Qing Yin, Department of Anus and Intestine Surgery, Qingzhou Hospital Affiliated to Shandong First Medical University, Qingzhou 262500, Shandong Province, China
Author contributions: Guo XB and Gao SS conceived of the presented idea and researched the background of the study; Zhang ZZ and Wang XB prepared the figures and tables; Ma Y and Yin GQ wrote the manuscript; all the authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China , No. 81672379 and No. 81101858 ; and Natural Science Foundation of Shandong Province , China, No. ZR2016HM16.
Conflict-of-interest statement: There is no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Bo Guo, PhD, Doctor, Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, No. 324 Jingwu Road, Huaiyin District, Jinan 250021, Shandong Province, China.
Received: February 21, 2022
Peer-review started: February 21, 2022
First decision: April 5, 2022
Revised: April 8, 2022
Accepted: May 28, 2022
Article in press: May 28, 2022
Published online: July 7, 2022
Processing time: 133 Days and 5.2 Hours
Peer-review started: February 21, 2022
First decision: April 5, 2022
Revised: April 8, 2022
Accepted: May 28, 2022
Article in press: May 28, 2022
Published online: July 7, 2022
Processing time: 133 Days and 5.2 Hours
Core Tip
Core Tip: Transcribed ultraconserved region (T-UCR) is abnormally expressed in gastric cancer (GC) cells and tumors. It has been found that a variety of T-UCR affects downstream genes and related pathways, and plays a regulatory role in the proliferation, migration and invasion of GC. However, there are few relevant reviews, and this paper aims to review the related studies of T-UCR in GC. And the function of T-UCR and its regulatory role in the occurrence and development of GC, thus providing a new strategy for the diagnosis and treatment of GC.